Differential Eye Movements in Mild Traumatic Brain Injury Versus Normal Controls
Differential Eye Movements in Mild Traumatic Brain Injury Versus Normal Controls
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DOI：
10.1097/htr.0000000000000036
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发表时间：
2015-01-01
影响因子：
2.4
通讯作者：
Carne, William
中科院分区：
文献类型：
--
作者：
Cifu, David X.;Wares, Joanna R.;Carne, William
目标：缺乏诊断和监测轻度创伤性脑损伤（mTBI）后症状改善的客观措施。计算机眼动追踪被认为是一种快速、用户友好且可现场使用的技术，可以满足这一需求。设计：通过头戴式、基于视频的双目眼动仪收集的眼动追踪数据用于检查患有脑震荡后综合症 (PCS) 的军人和无症状对照受试者的眼跳、注视和平稳追踪运动，以确定是否可以发现并量化眼动差异。参与者：60 名患有 PCS 的军人和 26 名无症状对照者。结果测量：mTBI 的诊断是通过研究理疗师的病史、体格检查和任何医疗记录的审查来确认的。分析了扫视、注视和平滑追踪眼球运动的各种特征。结果：有症状的 mTBI 受试者在统计学上具有较大的位置误差、较小的扫视幅度、较小的预测峰值速度、较小的峰值加速度和较长的持续时间。有症状的 mTBI 受试者也不太可能跟随目标运动（原发性眼跳较少）。一般来说，有症状的 mTBI 追踪逐步移动的目标不太准确，揭示了可能的大脑功能障碍。结论：开发了一种可靠、标准化的方案，似乎可以将 mTBI 与正常人区分开来，以供未来的研究使用。这项调查代表了客观识别 PCS 患者的一步。未来的研究需要集中于提高 PCS 患者眼动差异的特异性。
Objectives: Objective measures to diagnose and to monitor improvement of symptoms following mild traumatic brain injury (mTBI) are lacking. Computerized eye tracking has been advocated as a rapid, user friendly, and field-ready technique to meet this need. Design: Eye-tracking data collected via a head-mounted, video-based binocular eye tracker was used to examine saccades, fixations, and smooth pursuit movement in military Service Members with postconcussive syndrome (PCS) and asymptomatic control subjects in an effort to determine if eye movement differences could be found and quantified. Participants: Sixty Military Service Members with PCS and 26 asymptomatic controls. Outcome Measures: The diagnosis of mTBI was confirmed by the study physiatrist's history, physical examination, and a review of any medical records. Various features of saccades, fixation and smooth pursuit eye movements were analyzed. Results: Subjects with symptomatic mTBI had statistically larger position errors, smaller saccadic amplitudes, smaller predicted peak velocities, smaller peak accelerations, and longer durations. Subjects with symptomatic mTBI were also less likely to follow a target movement (less primary saccades). In general, symptomatic mTBI tracked the stepwise moving targets less accurately, revealing possible brain dysfunction. Conclusions: A reliable, standardized protocol that appears to differentiate mTBI from normals was developed for use in future research. This investigation represents a step toward objective identification of those with PCS. Future studies focused on increasing the specificity of eye movement differences in those with PCS are needed.