Daily Mean Temperature Affects Urolithiasis Presentation in Seoul: a Time-series Analysis.
Daily Mean Temperature Affects Urolithiasis Presentation in Seoul: a Time-series Analysis.
复制标题
DOI：
10.3346/jkms.2016.31.5.750
复制
发表时间：
2016-05
影响因子：
4.5
通讯作者：
Chang IH
中科院分区：
文献类型：
--
作者：
Lee S;Kim MS;Kim JH;Kwon JK;Chi BH;Kim JW;Chang IH
本研究旨在探讨首尔地区每日气温与尿石症症状之间的整体累积暴露反应及滞后反应关系。使用时间序列设计和分布滞后非线性方法，我们估计了尿石症表现与平均日温度相关的相对风险(RR)，包括20天期间的累积RR和单个日滞后20天的RR。我们分析了2005-2013年首尔4家医院急诊科14,518名寻求尿石症医疗评估或治疗的患者的数据。RR根据性别和年龄进行估算。日平均温度和尿石症表现之间的关系并不是单调的。此外，曝光-响应曲线形状和缔合强度在不同温度下有所不同，尽管在大多数情况下，温度高于13°C参考值时，RRS会增加。29°C对13°C尿路结石的相对危险度为2.54(95%可信区间：1.67~3.87)，男性为2.59(95%CI，1.56~4.32)，女性为2.42(95%CI，1.15~5.07)，40岁以下男性为3.83(95%CI，1.78~8.26)，40~60岁男性为2.47(95%CI，1.15~5.34)。在所有组中，在高温后5天内，均观察到出现尿石症的RR增加的一致趋势。在韩国大都市首尔，尿石症的表现随着气温的升高和日平均气温的升高而增加，最强的相关性估计只有几天的滞后。
This study aimed to investigate the overall cumulative exposure-response and the lag response relationships between daily temperature and urolithiasis presentation in Seoul. Using a time-series design and distributing lag nonlinear methods, we estimated the relative risk (RR) of urolithiasis presentation associated with mean daily temperature, including the cumulative RR for a 20 days period, and RR for individual daily lag through 20 days. We analyzed data from 14,518 patients of 4 hospitals emergency department who sought medical evaluation or treatment of urolithiasis from 2005-2013 in Seoul. RR was estimated according to sex and age. Associations between mean daily temperature and urolithiasis presentation were not monotonic. Furthermore, there was variation in the exposure-response curve shapes and the strength of association at different temperatures, although in most cases RRs increased for temperatures above the 13°C reference value. The RRs for urolothiasis at 29°C vs. 13°C were 2.54 in all patients (95% confidence interval [CI]: 1.67-3.87), 2.59 in male (95% CI, 1.56-4.32), 2.42 in female (95% CI, 1.15-5.07), 3.83 in male less than 40 years old (95% CI, 1.78-8.26), and 2.47 in male between 40 and 60 years old (95% CI, 1.15-5.34). Consistent trends of increasing RR of urolithiasis presentation were observed within 5 days of high temperatures across all groups. Urolithiasis presentation increased with high temperature with higher daily mean temperatures, with the strongest associations estimated for lags of only a few days, in Seoul, a metropolitan city in Korea.