Nanoscale covalent organic frameworks: from controlled synthesis to cancer therapy.
Nanoscale covalent organic frameworks: from controlled synthesis to cancer therapy.
复制标题
纳米级共价有机框架：从控制合成到癌症治疗。
DOI：
10.1039/d1cc04846e
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发表时间：
2021-11
影响因子：
4.9
通讯作者：
Xuexue He;Zhenqi Jiang;O. Akakuru;Juan Li;A. Wu
中科院分区：
文献类型：
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作者：
Xuexue He;Zhenqi Jiang;O. Akakuru;Juan Li;A. Wu
共价有机骨架作为一种新型的结晶型多孔材料，主要由轻质元素(H、B、C、N、O)通过动态共价键连接形成二维或三维的周期性结构。碳纤维具有密度低、比表面积大、孔径可调等特点，在储能分离、催化、传感、生物医学等领域显示出巨大的潜力。然而，与金属有机骨架相比，其相对较大的尺寸和不规则的形态影响了其在体内的生物相容性和生物利用度，从而阻碍了其进一步的生物医学应用。本文重点介绍了纳米COFS的可控设计策略、用于生物医学的NCOF的独特性质以及用于癌症治疗的NCOF的最新进展。此外，还提出了目前NCOF在生物医学上应用的挑战和进一步改进的前景。
Covalent organic frameworks (COFs), as a new type of crystalline porous materials, mainly consist of light-weight elements (H, B, C, N and O) linked by dynamic covalent bonds to form periodical structures of two or three dimensions. As an attribute of their low density, large surface area, and excellent adjustable pore size, COFs show great potential in many fields including energy storage and separation, catalysis, sensing, and biomedicine. However, compared with metal organic frameworks (MOFs), the relatively large size and irregular morphology of COFs affect their biocompatibility and bioavailability in vivo, thus impeding their further biomedical applications. This Review focuses on the controlled design strategies of nanoscale COFs (NCOFs), unique properties of NCOFs for biomedical applications, and recent progress in NCOFs for cancer therapy. In addition, current challenges for the biomedical use of NCOFs and perspectives for further improvements are presented.