POTENTIATION OF THE EFFECTS OF REWARD-RELATED STIMULI BY DOPAMINERGIC-DEPENDENT MECHANISMS IN THE NUCLEUS-ACCUMBENS
POTENTIATION OF THE EFFECTS OF REWARD-RELATED STIMULI BY DOPAMINERGIC-DEPENDENT MECHANISMS IN THE NUCLEUS-ACCUMBENS
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DOI：
10.1007/bf02246039
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发表时间：
1991-01-01
影响因子：
3.4
通讯作者：
ROBBINS, TW
中科院分区：
文献类型：
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作者：
CADOR, M;TAYLOR, JR;ROBBINS, TW
三个实验研究的行为，药理学和神经特异性的先前报道的增强反应条件强化后，内阿替宾d-苯丙胺，通过研究内阿替宾多巴胺（DA）和去甲肾上腺素的影响，使用一个新的响应程序的收购。 在实验1中，脑内DA输注的影响（5，20，50 μ g/2 μ l）在四种条件下进行比较：（i）在训练期间条件刺激（CS）和水的正配对后的内-多巴胺;（ii）作为（i）但也在DA受体拮抗剂α-氟哌噻吨的全身剂量后;结果表明，只有尾状核内DA在正配对条件下才有显著的剂量依赖性增加，而尾状核内DA在正配对条件下才有显著的剂量依赖性增加。 在实验2中，研究了较高剂量范围（20，100，200 μ g）和较小输注体积（5，25，50 μ g/1 μ l）的多巴胺内注射的效果，并与相似剂量范围（5，25，50 μ g/1 μ l）的去甲肾上腺素（NA）内注射进行了比较。 只有DA产生了选择性的，剂量依赖性的增加与条件强化反应。 在实验3中，使用6-羟基多巴胺产生深刻的（约90%）消耗皮质和核多巴胺NA水平的背侧去甲肾上腺素能束（DNAB）的神经毒性病变对增加的反应没有影响，条件强化由内多巴胺d-苯丙胺（3，10，30 μ g/1 μ l）。 结果进行了讨论，在神经化学调解的增强条件反射的效果，由d-安非他明和DA-依赖的机制，在奖励相关的过程中的作用的核reverbens。
Three experiments examined the behavioural, pharmacological and neural specificity of the previously reported potentiation of responding with conditioned reinforcement following intra-accumbens d-amphetamine, by studying the effects of intra-accumbens dopamine (DA) and noradrenaline, using an acquisition of a new response procedure. In experiment 1, the effects of intra-cerebral DA infusions (5, 20, 50-mu-g/2-mu-l) were compared in four conditions: (i) intra-accumbens DA following positive pairing of the conditioned stimulus (CS) and water during training; (ii) as (i) but also following a systemic dose of the DA receptor antagonist alpha-flupenthixol; (iii) intra-accumbens DA following random pairing of the CS and water during training; and (iv) as (i) but with intra-caudate rather than intra-accumbens DA. The results showed that only with intra-accumbens DA in the positive pairing condition was there a significant dose-dependent increase in responding. In experiment 2, the effects of a higher range of doses (20, 100, 200-mu-g) and smaller infusion volume (5, 25, 50-mu-g/1-mu-l) of intra-accumbens DA were studied, in comparison with a similar range of doses (5, 25, 50-mu-g/1-mu-l) of intra-accumbens noradrenaline (NA). Only DA produced a selective, dose-dependent increase in responding with conditioned reinforcement. In experiment 3 neurotoxic lesions of the dorsal noradrenergic bundle (DNAB) using 6-hydroxydopamine producing profound (about 90%) depletion of cortical and nucleus accumbens NA levels had no effect on the increased responding with conditioned reinforcement produced by intra-accumbens d-amphetamine (3, 10, 30-mu-g/1-mu-l). The results are discussed in terms of the neurochemical mediation of the potentiation of the effects of conditioned reinforcers by d-amphetamine and the role of DA-dependent mechanisms of the nucleus accumbens in reward-related processes.