Effect of repeated exposures to nitrogen dioxide and sulfuric acid mist alone or in combination on mucociliary clearance from the lungs of rabbits.
Effect of repeated exposures to nitrogen dioxide and sulfuric acid mist alone or in combination on mucociliary clearance from the lungs of rabbits.
复制标题
单独或组合重复暴露于二氧化氮和硫酸雾对兔子肺部粘液纤毛清除的影响。
DOI：
10.1016/s0013-9351(87)80238-4
复制
发表时间：
1987
影响因子：
8.3
通讯作者：
Vollmuth,TA
中科院分区：
文献类型：
--
作者：
Schlesinger,RB;Driscoll,KE;Vollmuth,TA
对环境空气污染的生物反应可能是污染物的特定组合的函数。将兔组暴露于NO2（0.3 ppm或1 ppm），含和不含H2SO 4（0.5 mg/m3），每天2小时，持续14天，以评估对气管支气管树中示踪颗粒的粘膜纤毛清除的影响。暴露于NO2并没有改变清除，而暴露于H2SO 4产生了延迟对曝光系列的中间。0.3 ppm NO2与H2SO 4的组合导致清除速度加快，而使用1 ppm NO2与酸的混合物与对照相比没有变化。这些结果强调了对污染物混合物进行研究的重要性，因为并不总是能够从审查个别污染物影响的研究中推断出反应。
The biological response to ambient air pollution may be a function of specific combinations of pollutants. Groups of rabbits were exposed to NO2(0.3 ppm or 1 ppm) with and without H2SO4(0.5 mg/m3) for 2 hr/day for up to 14 days for assessment of effects upon mucociliary clearance of tracer particles from the tracheobronchial tree. Exposure to NO2did not alter clearance, while exposure to H2SO4produced a retardation toward the middle of the exposure series. The combination of 0.3 ppm NO2with H2SO4resulted in a speeding of clearance, while no change from control was seen with the mixture employing 1 ppm NO2with acid. These results emphasize the importance of performing studies with pollutant mixtures, since it is not always possible to extrapolate responses from studies examining effects of individual pollutants.