The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia
The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia
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DOI：
10.1016/j.biomaterials.2010.01.016
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发表时间：
2010-04-01
期刊：
影响因子：
14
通讯作者：
Koyano, Kiyoshi
中科院分区：
文献类型：
--
作者：
Masuzaki, Tomohiro;Ayukawa, Yasunori;Koyano, Kiyoshi
本研究的目的是评估新开发的可注射的聚（乳酸-共-乙醇酸）（PLGA）微球含有氟伐他汀对周围的钛种植体在大鼠胫骨骨生成的影响。在通过体外测定确认氟伐他汀从微球的持续释放曲线后，通过单次经皮注射将微球施用至大鼠的背部皮肤。在种植手术后2周和4周，氟伐他汀组显示钛种植体周围新骨形成增强，而对血清生化没有任何影响。此外，氟伐他汀组显示股骨的三点弯曲强度增加。本研究的结果表明，一个单一的远程注射PLGA/氟伐他汀微球安全，成功地刺激钛种植体周围的骨形成，并增加骨的机械性能。(C)2010爱思唯尔有限公司保留所有权利。
The aim of this study was to evaluate the effects of newly developed injectable poly (lactic-co-glycolic acid) (PLGA) microspheres containing fluvastatin on osteogenesis around titanium implants in the rat tibia. After confirmation of the sustained-release profile of fluvastatin from the microspheres by an in vitro assay, the microspheres were administered to the back skin of the rats by a single transdermal injection. At 2 and 4 weeks after the implant surgery, the fluvastatin groups showed enhanced new bone formation around the titanium implants without any influence on the serum biochemistry. In addition, the fluvastatin groups showed increased three-point bending strengths of their femurs. The results of this study indicate that a single remote injection of PLGA/fluvastatin microspheres safely and successfully stimulated bone formation around titanium implants and increased the mechanical properties of bone. (C) 2010 Elsevier Ltd. All rights reserved.