The endothelial protein C receptor
The endothelial protein C receptor
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DOI：
10.1097/01.moh.0000239712.93662.35
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发表时间：
2006-09-01
影响因子：
3.2
通讯作者：
Esmon, Charles T.
中科院分区：
文献类型：
--
作者：
Esmon, Charles T.
综述目的内皮细胞蛋白C受体是调节天然抗凝功能和活化蛋白C的抗炎和抗凋亡功能的关键。这导致预测内皮细胞蛋白C受体的异常可能与血栓形成倾向的改变和对感染因子的炎症反应有关。本文综述了近年来发现的内皮细胞蛋白C受体的遗传和获得性异常与疾病病理生理过程有关的最新证据，在小鼠中，内皮细胞蛋白C受体表达的增加和减少可调节凝血和炎症过程。基因多态性与蛋白质表达和家族性和获得性血栓性diseases.SummaryThe新出现的临床证据表明，内皮细胞蛋白C受体参与血栓性疾病的内皮细胞蛋白C受体基因型的理解和自身抗体的知识可能有助于诊断患者血栓性事件的风险。
Purpose of reviewThe endothelial cell protein C receptor is known to be critical for the regulation of natural anticoagulant functions and some anti-inflammatory and anti-apoptotic functions of activated protein C. This leads to the prediction that abnormalities in endothelial cell protein C receptor might be associated with altered thrombotic tendencies and hyperinflammatory responses to infectious agents. This review covers the most recent evidence that relatively common genetic and acquired abnormalities of endothelial cell protein C receptor do contribute to pathophysiological disease processes.Recent findingsIn mice, increases and decreases in endothelial cell protein C receptor expression are shown to modulate the coagulation and inflammatory proceses. Genetic polymorphisms are associated with alterations in protein expression and familial and acquired thrombotic disease.SummaryThe emerging clinical evidence of endothelial cell protein C receptor involvement in thrombotic disease suggests that the understanding of endothelial cell protein C receptor genotype and the knowledge of auto-antibodies may aid in diagnosing the risk of thrombotic events in patients.