Cardiff Depression Study - A sib-pair study of life events and familiality in major depression
Cardiff Depression Study - A sib-pair study of life events and familiality in major depression
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DOI：
10.1192/bjp.176.2.150
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发表时间：
2000-02-01
影响因子：
10.5
通讯作者：
McGuffin, P
中科院分区：
文献类型：
--
作者：
Farmer, A;Harris, T;McGuffin, P
背景与对照组相比，抑郁症先证者的一级亲属中抑郁症和不良事件的发生率高。目的探讨生活事件与抑郁症的相似性，以及是否存在影响抑郁易感性和生活事件经历的共同家族因素。对108例抑郁症先证者及其同胞与105例健康对照者及其同胞的精神病理学和生活事件进行比较。与对照组的兄弟姐妹相比，抑郁症患者的兄弟姐妹患抑郁症的相对危险度为9.74，尽管这两组在life eve：nts测量中没有差异。几类事件显示出显著的同胞相关性。结论虽然抑郁症有很强的家族性，但家庭对生活事件的影响主要是由共同的经历来解释的。没有证据表明抑郁症和生活事件有共同的影响因素。利益声明这项研究是由欢迎信托基金资助的。
Background An excess of both depression and undesirable lire events ii first-degree relatives of probands with depression as compared with controls has been reported. This association may have reflected a familial factor in common.Aims To examine the familiality of life events and depression and whether there may be a common familial factor influencing vulnerability to depression and the experiencing of lire events.Method In a sib-pair design, 108 probands with depression and their siblings were compared with 105 healthy controls and their siblings for psychopathology and life events.Results The lifetime relative risk of depressive disorder in the siblings of depressed subjects as compared with siblings of controls was 9.74, although these groups did not differ in the life eve:nts measures. Several categories of events showed significant sibling correlations. but this was due to the same event affecting both members of the pair.Conclusions Although depressive disorder was strongly familial, the familial effects on life events were largely explained by shared experiences. There was no evidence for a common factor influencing both depression and life events.Declaration of interest The study was funded by a project grant from the Welcome Trust.