Dynamics in the solid-state: perspectives for the investigation of amyloid aggregates, membrane proteins and soluble protein complexes
Dynamics in the solid-state: perspectives for the investigation of amyloid aggregates, membrane proteins and soluble protein complexes
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DOI：
10.1007/s10858-014-9822-6
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发表时间：
2014-05-01
影响因子：
2.7
通讯作者：
Reif, Bernd
中科院分区：
文献类型：
--
作者：
Linser, Rasmus;Sarkar, Riddhiman;Reif, Bernd
由淀粉样蛋白肽和蛋白质形成的聚集体与重构的膜蛋白制剂在固态核磁共振实验中显示的光谱质量方面存在显着差异。结构异质性和动力学原则上都可以解释这一观察结果。这篇观点文章旨在指出这些系统研究中的挑战和局限性，以及潜在的机遇。
Aggregates formed by amyloidogenic peptides and proteins and reconstituted membrane protein preparations differ significantly in terms of the spectral quality that they display in solid-state NMR experiments. Structural heterogeneity and dynamics can both in principle account for that observation. This perspectives article aims to point out challenges and limitations, but also potential opportunities in the investigation of these systems.