ALCOHOL-CONSUMPTION AND RISK OF LEUKEMIA, NON-HODGKINS-LYMPHOMA, AND MULTIPLE-MYELOMA
ALCOHOL-CONSUMPTION AND RISK OF LEUKEMIA, NON-HODGKINS-LYMPHOMA, AND MULTIPLE-MYELOMA
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DOI：
10.1016/0145-2126(92)90077-k
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发表时间：
1992-10-01
影响因子：
2.7
通讯作者：
BLAIR, A
中科院分区：
文献类型：
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作者：
BROWN, LM;GIBSON, R;BLAIR, A
对来自爱荷华州和明尼苏达州的578名白血病患者、622名非霍奇金淋巴瘤患者和820名对照者以及来自爱荷华州的173名多发性骨髓瘤患者和452名对照者进行了基于人群的病例对照访谈研究，为研究这些癌症与饮酒的关系提供了机会。虽然饮酒者患白血病特定亚型（急性淋巴细胞白血病（OR = 3.0），骨髓增生异常（OR = 1.6）和其他白血病（OR = 1.5））和多发性骨髓瘤（OR = 1.3）的风险无显著增加，但没有统计学显著性发现，也没有饮酒量的剂量反应梯度。因此，这些数据表明，酒精不是淋巴和造血肿瘤的病因学的重要贡献者。
Population-based case-control interview studies of white men, 578 with leukemia, 622 with non-Hodgkin's lymphoma, and 820 controls from Iowa and Minnesota and 173 with multiple myeloma and 452 controls from Iowa, offered the opportunity to investigate the relationship of these cancers with alcohol consumption. Although drinkers had non-significantly elevated risks for specific subtypes of leukemia (acute lymphocytic leukemia (OR = 3.0), myelodysplasia (OR = 1.6), and other leukemia (OR = 1.5)) and multiple myeloma (OR = 1.3), there were no statistically significant findings and no dose-response gradients with amount of alcohol consumed. Thus, these data suggest that alcohol is not an important contributor to the etiology of lymphatic and hematopoietic tumors.