Hepatic ischemia reperfusion injury: A systematic review of literature and the role of current drugs and biomarkers
Hepatic ischemia reperfusion injury: A systematic review of literature and the role of current drugs and biomarkers
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DOI：
10.1016/j.ijsu.2016.05.050
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发表时间：
2016-09-01
影响因子：
15.3
通讯作者：
Nardo, Bruno
中科院分区：
文献类型：
--
作者：
Cannistra, Marco;Ruggiero, Michele;Nardo, Bruno
肝脏缺血再灌注损伤（liver ischemia - reperfusion injury， IRI）不仅是一个涉及肝脏的病理生理过程，而且是一个影响多组织器官的复杂全身性过程。肝IRI可严重损害肝功能，甚至产生不可逆的损伤，引起多器官功能障碍的级联反应。许多因素，包括无氧代谢、线粒体损伤、氧化应激和ROS的分泌、细胞内Ca2+超载、KCs和中性粒细胞产生的细胞因子和趋化因子以及NO，都参与了肝脏IRI过程的调节。基质金属蛋白酶（MMPs）可能是早期白细胞募集的重要介质和急性和慢性肝损伤相关的缺血靶点。MMPs和中性粒细胞明胶酶相关脂钙蛋白（NGAL）可作为I-R损伤严重程度分期的标志。这篇综述探讨了表征肝脏IRI、MMPs的因素和炎症途径之间的关系以及目前治疗这种疾病的药理学方法。(C) 2016 IJS出版集团有限公司Elsevier Ltd.出版。版权所有。
Hepatic ischemia reperfusion injury (IRI) is not only a pathophysiological process involving the liver, but also a complex systemic process affecting multiple tissues and organs. Hepatic IRI can seriously impair liver function, even producing irreversible damage, which causes a cascade of multiple organ dysfunction. Many factors, including anaerobic metabolism, mitochondrial damage, oxidative stress and secretion of ROS, intracellular Ca2+ overload, cytokines and chemokines produced by KCs and neutrophils, and NO, are involved in the regulation of hepatic IRI processes.Matrix Metalloproteinases (MMPs) can be an important mediator of early leukocyte recruitment and target in acute and chronic liver injury associated to ischemia. MMPs and neutrophil gelatinase-associated lipocalin (NGAL) could be used as markers of I-R injury severity stages.This review explores the relationship between factors and inflammatory pathways that characterize hepatic IRI, MMPs and current pharmacological approaches to this disease. (C) 2016 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.