Targeting senescent dermal fibroblasts responsible for hyperactive melanocytes in melasma.
Targeting senescent dermal fibroblasts responsible for hyperactive melanocytes in melasma.
复制标题
靶向衰老的皮肤成纤维细胞负责过度活跃的黑色素细胞在黄褐斑。
DOI：
10.1097/cm9.0000000000002488
复制
发表时间：
2023-07-05
影响因子：
6.1
通讯作者：
中科院分区：
文献类型：
--
作者：
Melasma (chloasma) is a highly prevalent and cosmetically disfiguring pigmented skin disease that mainly manifests as bilateral irregular brown macules on sun-exposed areas of the face.[1] Although melasma causes no physical discom-fort, it poses a significant psychological burden on patients due to distressing cosmetic concerns. The sustained epidermal hypermelanization is a prominent pathological feature of melasma, which is usually considered to result from melanin overproduction by hyperactive melanocytes.[2] However, existing therapeutic interventions that suppress melanocytes and tyrosinase, the rate-limiting enzyme in the synthetic pathway of melanin pigments, fail to achieve satisfactory outcomes, especially for recalcitrant melasma patients whose lesions tend to rebound.[2]In recent years, it has been demonstrated that melasma is not simply a pigmentary disorder only attributable to overactive melanocytes but may also involve senescent dermal fibroblasts and dysfunctional vascular endothelial cells as well as subtle inflammation mediated by activated mast cells.[3] Therefore, we summarize the most up-to-date literature to explore the roles of senescent dermal fibroblasts in the pathogenesis of melasma and also highlight several novel concept-directed treatments for melasma.
影响因子：
1.6
作者：
Kwon SH;Na JI;Huh CH;Park KC
通讯作者：
Park KC
影响因子：
3.4
作者：
Gulfan, Ma Christina B.;Wanitphakdeedecha, Rungsima;Wongdama, Supisara;Jantanapornchai, Nuttagarn;Yan, Chadakan;Rakchart, Sarawalai
通讯作者：
Rakchart, Sarawalai