Carbaryl exposure and incident cancer in the Agricultural Health Study
Carbaryl exposure and incident cancer in the Agricultural Health Study
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DOI：
10.1002/ijc.22836
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发表时间：
2007-10-15
影响因子：
6.4
通讯作者：
Alavanja, Michael C. R.
中科院分区：
文献类型：
--
作者：
Mahajan, Rajeev;Blair, Aaron;Alavanja, Michael C. R.
西维因是一种氨基甲酸酯杀虫剂，在农业、商业和家庭环境中具有广泛用途。此前曾将其与非霍奇金淋巴瘤（NHL）联系起来，但对人类癌症风险的研究有限。我们在农业健康研究中检查了职业西维因的使用和所有癌症的风险，这是一项针对北卡罗来纳州和爱荷华州一组农药施用者的前瞻性研究。该分析包括 1993 年至 1997 年期间登记的 21,416 名受试者（1,291 例），并跟踪了 2003 年的癌症发病率。农药暴露和其他数据是通过自填问卷收集的。泊松回归用于计算比率 (RR) 和 95% 置信区间 (Cls)，同时控制潜在的混杂因素。西维因总体上与癌症风险无关。相对于从未使用过西维因的受试者，黑色素瘤风险随终生暴露天数 >175 天（RR = 4.11；95%CI，1.33-12.75；p-趋势 = 0.07）、使用 >10 年（RR 3.19；95%CI，1.28-7.92；p-趋势 = 0.04）或每年使用 >10 天而升高。 （RR = 5.50；95%CI，2.19-13.84；p 趋势 < 0.001）。调整阳光照射后，风险仍然存在。虽然不显着，但随着暴露水平的增加，前列腺癌风险似乎呈降低趋势。使用一些（但不是全部）暴露措施观察到 NHL 风险略有增加。没有观察到与其他检查的癌症部位的关联。由于观察到的结果不是先验假设的，并且对其生物学合理性的研究有限，因此应谨慎解释。 (C) 2007 Wiley-Liss, Inc.
Carbaryl is a carbamate insecticide with a broad spectrum of uses in agricultural, commercial and household settings. It has previously been linked with non-Hodgkin lymphoma (NHL) but studies of cancer risk in humans are limited. We examined occupational carbaryl use and risk of all cancers in the Agricultural Health Study, a prospective study of a cohort of pesticide applicators in North Carolina and Iowa. This analysis included 21,416 subjects (1,291 cases) enrolled from 1993-1997 and followed for cancer incidence through 2003. Pesticide exposure and other data were collected using self-administered questionnaires. Poisson regression was used to calculate rate ratios (RRs) and 95% confidence intervals (Cls) while controlling for potential confounders. Carbaryl was not associated with cancer risk overall. Relative to subjects who never used carbaryl, melanoma risk was elevated with >175 lifetime exposure-days (RR = 4.11; 95%CI, 1.33-12.75; p-trend = 0.07), >10 years of use (RR 3.19; 95%CI, 1.28-7.92; p-trend = 0.04), or >10 days of use per year (RR = 5.50; 95%CI, 2.19-13.84; p-trend < 0.001). Risk remained after adjusting for sunlight exposure. Although not significant, there appeared to be a trend of decreasing prostate cancer risk with increasing level of exposure. A small increase in NHL risk was observed using some, but not all, exposure measures. No associations were observed with other examined cancer sites. Because the observed results were not hypothesized a priori and because of limited study of their biological plausibility, they should be interpreted with caution. (C) 2007 Wiley-Liss, Inc.