Paired neurophysiological and clinical study of the brainstem at different stages of Parkinson's Disease
Paired neurophysiological and clinical study of the brainstem at different stages of Parkinson's Disease
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DOI：
10.1016/j.clinph.2014.12.017
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发表时间：
2015-10-01
影响因子：
4.7
通讯作者：
Deriu, F.
中科院分区：
文献类型：
--
作者：
De Natale, E. R.;Ginatempo, F.;Deriu, F.
目的：通过一系列前庭诱发肌源性电位（VEMPs）研究帕金森病（PD）不同阶段的脑干功能，并将结果与临床量表评分进行比较，以评估与脑干受累相关的症状的存在。记录早期PD患者的颈部、咬肌和眼部VEMP（n = 14，疾病持续时间1.42 +/-0.7年），晚期PD（n = 19，疾病持续时间7.26 +/-2.9年）和27个年龄匹配的对照。结果：PD组VEMPs改变率明显高于对照组（P < 0.001），但各组间差异无统计学意义（P> 0.05）。然而，早期和晚期PD表现出不同的异常模式（p = 0.02），前者普遍存在潜伏期延迟，而后者则不存在。VEMP损伤直接相关的RBD-SQ评分在两个PD队列和反向与迷你BESTest评分在先进的PD.Conclusions：VEMPs显示渐进的严重程度的变化在不同阶段的PD，与存在的姿势不稳定和RBD的显着相关性。意义：联合使用VEMPs可能会提供有趣的见解PD的病理生理机制在疾病的最早期和前驱期。(C)2015年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To study brainstem function in Parkinson's Disease (PD) at different stages, through a battery of vestibular- evoked myogenic potentials (VEMPs) and compare the results with scores on clinical scales assessing the presence of symptoms linked to brainstem involvement.Methods: Cervical, masseter and ocular VEMPs were recorded in patients with early PD (n = 14, disease duration 1.42 +/- 0.7 years), advanced PD (n = 19, disease duration 7.26 +/- 2.9 years) and in 27 age- matched controls. In PD, the following clinical scales were administered: Mini-BESTest, REM sleep Behavior Disorder Screening Questionnaire (RBD-SQ), PD Sleep Scale, Epworth Sleepiness Scale and Geriatric Depression Scale.Results: Rate of VEMPs alterations was higher (p < 0.001) in PD than controls, but similar within PD groups. However, early and advanced PD showed a different pattern of abnormalities (p = 0.02), being latency delay prevalent in the former and absence in the latter. VEMP impairment correlated directly with RBD-SQ scores in both PD cohorts and inversely with Mini- BESTest scores in advanced PD.Conclusions: VEMPs displayed progressive severity of alterations at different stages of PD, with remarkable correlations with presence of postural instability and RBD.Significance: The combined use of VEMPs may provide interesting insights into the pathophysiological mechanisms of PD at the earliest and prodromal stage of the disease. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.