Nonsteroidal antiinflammatory drugs differentially suppress endometriosis in a murine model
Nonsteroidal antiinflammatory drugs differentially suppress endometriosis in a murine model
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DOI：
10.1016/j.fertnstert.2004.06.058
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发表时间：
2005-01-01
影响因子：
6.7
通讯作者：
Rupnick, MA
中科院分区：
文献类型：
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作者：
Efstathiou, JA;Sampson, DA;Rupnick, MA
目的：确定非甾体抗炎药 (NSAID) 是否影响小鼠模型中子宫内膜异位病变的形成和进展。设计：对手术诱导的腹部/腹膜子宫内膜异位症小鼠模型进行药物干预。环境：动物研究机构。患者：自体子宫内膜植入后，将小鼠随机分组，并用几种 NSAID 之一或载体匹配对照治疗 4 周。结果测量：子宫内膜异位病变的形成、生长和总负担。结果：非甾体抗炎药不同程度地抑制病变的形成和生长，从而显着减轻疾病负担。与对照组 (5.7 +/- 2.3 mm(2)) 相比，塞来昔布 (1.3 +/- 1.2 mm(2))、吲哚美辛 (1.4 +/- 1.4 mm(2))、萘普生 (2.7 +/- 1.2 mm(2))、舒林酸 (3.1 +/- 1.5 mm(2))、罗非考昔可减轻病变负担（3.4 +/- 3.0 毫米（2））和布洛芬（4.1 +/- 1.4 毫米（2））。相比之下，阿司匹林（5.9 +/- 1.2 mm(2)）没有统计学上的显着效果。通过对塞来昔布治疗的小鼠进行阴道检查和涂片检查，证实了不间断的发情周期。 结论：长期服用某些非甾体抗炎药可限制该小鼠模型中子宫内膜异位症的进展。数据表明，子宫内膜异位症治疗中非甾体抗炎药的选择应扩展到疼痛管理之外，以最大限度地抑制疾病负担。 (C)2005 年，美国生殖医学会。
Objective: To determine whether nonsteroidal antiinflammatory drugs (NSAIDs) affect the establishment and progression of endometriotic lesions in a murine model.Design: Pharmacologic intervention in a surgically induced murine model of abdominal/peritoneal endometriosis.Setting: Animal research facility.Patient(s): After implantation of autologous endometrium, mice were randomized into groups and treated with one of several NSAIDs or the vehicle-matched control for 4 weeks.Main Outcome Measure(s): Establishment, growth, and total burden of endometriotic lesions.Result(s): The NSAIDs differentially inhibited lesion establishment and growth, resulting in significantly reduced disease burden. Compared with controls (5.7 +/- 2.3 mm(2)), lesion burden was reduced by celecoxib (1.3 +/- 1.2 mm(2)), indomethacin (1.4 +/- 1.4 mm(2)), naproxen (2.7 +/- 1.2 mm(2)), sulindac (3.1 +/- 1.5 mm(2)), rofecoxib (3.4 +/- 3.0 mm(2)), and ibuprofen (4.1 +/- 1.4 mm(2)). In contrast, aspirin (5.9 +/- 1.2 mm(2)) had no statistically significant effect. Uninterrupted estrus cycling was confirmed by vaginal exams and smears in celecoxib-treated mice.Conclusion(s): Chronic administration of certain NSAIDs limits the progression of endometriosis in this murine model. The data suggest that NSAID selection in the treatment of endometriosis should be extended beyond pain management to maximize the inhibitory effect on disease burden. (C)2005 by American Society for Reproductive Medicine.