Histocompatibility as Adaptive Response to Discriminatory Within-Organism Conflict: A Historical Model
Histocompatibility as Adaptive Response to Discriminatory Within-Organism Conflict: A Historical Model
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DOI：
10.1086/679442
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发表时间：
2015-02-01
影响因子：
2.9
通讯作者：
Gilbert, Owen M.
中科院分区：
文献类型：
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作者：
Gilbert, Owen M.
多细胞组织相容性，或组织相容性，限制了近亲的融合。组织相容性取决于高变量线索基因，在一个群体中，这些基因通常有100多个等位基因。为了解释组织相容性的演变，我在这里采取了历史的方法。我把重点放在海洋无脊椎动物组织相容性的具体例子上。我使用简单的博弈论模型来说明组织相容性可以通过五个步骤来进化。这些步骤包括不分青红皂白融合的进化、歧视性组织内冲突的进化、次要组织亲和性的进化、主要组织亲和性的进化和主要组织相容性线索多态的进化。允许循序渐进的进化揭示了歧视性的有机体内冲突，作为组织相容性和相关线索多态的选择性压力。来自海洋无脊椎动物和其他生物的现有数据与这一假设是一致的。
Multicellular tissue compatibility, or histocompatibility, restricts fusion to close kin. Histocompatibility depends on hypervariable cue genes, which often have more than 100 alleles in a population. To explain the evolution of histocompatibility, I here take a historical approach. I focus on the specific example of marine invertebrate histocompatibility. I use simple game-theoretical models to show that histocompatibility can evolve through five steps. These steps include the evolution of indiscriminate fusion, the evolution of discriminatory within-organism conflict, the evolution of minor histocompatibility, the evolution of major histocompatibility, and the evolution of major histocompatibility cue polymorphism. Allowing for gradual evolution reveals discriminatory within-organism conflict as a selective pressure for histocompatibility and associated cue polymorphism. Existing data from marine invertebrates and other organisms are consistent with this hypothesis.