Maladaptive metacognitive beliefs mediated the effect of intolerance of uncertainty on depression
Maladaptive metacognitive beliefs mediated the effect of intolerance of uncertainty on depression
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DOI：
10.1002/cpp.2589
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发表时间：
2021-04-13
影响因子：
3.6
通讯作者：
Lei, Wei
中科院分区：
文献类型：
--
作者：
Chen, Jing;Tan, Youguo;Lei, Wei
不确定不耐受(IU)和不适应的元认知信念(MBS)都与抑郁有关。然而，MBS和Iu在临床抑郁症中的关系尚不清楚。本研究旨在研究重度抑郁障碍(MDD)患者MBS和Iu的可能损害，并探讨这两个因素与抑郁症状的关系。采用元认知问卷(McQ-30)、不确定不容忍量表(IUS-12)和临床评定量表对53例MDD患者和56例健康对照(HCS)进行测评。采用逐步回归分析探讨MBS和Iu对抑郁的独立作用。中介分析用于检验变量之间的关联性。MDD患者的IUS-12和McQ-30得分高于HCS患者。逐步回归显示，在控制年龄、性别、焦虑症状和IU的影响的同时，关于不控制思想的后果的负向MBS(McQ-NC)对抑郁症状的影响具有独特的贡献。McQ-NC和关于消极思维的不可控性和危险性的负性MBS(McQ-NEG)完全中介了IU对抑郁和焦虑症状的影响。我们的结果提供了明确的证据，表明适应不良的负性MBS与抑郁症状直接相关，并在Iu对抑郁和焦虑症状的影响中起中介作用，提示Iu和MBS对临床症状的影响是分级的。
Both elevated intolerance of uncertainty (IU) and maladaptive metacognitive beliefs (MBs) were associated with depression. However, the relationship between MBs and IU in clinical depression is unclear. The current study aimed to investigate the putative impairment of MBs and IU in major depressive disorder (MDD) and explore the relationship between these two factors with depressive symptoms. Metacognition Questionnaire-30 Items (MCQ-30), Intolerance of Uncertainty Scale-Short Form (IUS-12) and clinical rating scales were administered to 53 patients with MDD and 56 healthy controls (HCs). Stepwise regressions were performed to explore independent contributions of MBs and IU on depression. Mediation analysis was used to examine associations among variables. Patients with MDD reported higher IUS-12 and MCQ-30 scores than HCs. Stepwise regressions revealed a unique contribution of negative MBs concerning the consequences of not controlling thoughts (MCQ-NC) on depression symptoms while controlling the effects of age, gender, anxiety symptoms and IU. MCQ-NC and negative MBs concerning the uncontrollability and danger of negative thinking (MCQ-NEG) completely mediated the effects of IU on depression and anxiety symptoms. Our results provided clear evidence that maladaptive negative MBs are directly associated with depression symptoms, and mediated the effect of IU on depression and anxiety symptoms, suggesting that IU and MBs influence clinical symptoms in a hierarchical manner.