A cluster of transfusion-associated babesiosis cases traced to a single asymptomatic donor
A cluster of transfusion-associated babesiosis cases traced to a single asymptomatic donor
复制标题
DOI：
10.1001/jama.281.10.927
复制
发表时间：
1999-03-10
影响因子：
120.7
通讯作者：
Wittner, M
中科院分区：
文献类型：
--
作者：
Dobroszycki, J;Herwaldt, BL;Wittner, M
研究背景输血引起巴贝斯虫病的危险性在很大程度上是未知的，因为在巴贝斯虫病流行的地区，巴贝斯虫病通常是无症状感染。目的调查和治疗大量输血相关的巴贝斯虫病病例，设计病例系列和流行病学调查。主要结果测量诊断和成功治疗的巴贝虫病后transfusion.Results六个人（1名成人，1名儿童和4名新生儿）暴露于产品从一个无症状的巴贝虫感染的捐助者的单次献血。使用聚合酶链反应试验、动物接种研究和间接免疫荧光抗体试验确认供体血液中存在小巴氏杆菌，并确定6名受体中有3名存在感染，3例感染受者和1例额外受者均接受了治疗，未发生任何意外。结论临床医师应考虑巴贝斯虫病的鉴别诊断输血后出现发热性溶血性疾病及时诊断很重要，因为巴贝虫病对抗生素治疗有反应，如果不治疗，在某些风险群体中可能是致命的疾病。
Context The risk of acquiring babesiosis by blood transfusion is largely unknown since in areas where it is endemic it is often an asymptomatic infection.Objective To investigate and treat a duster of blood transfusion-associated babesiosis cases,Design Case series and epidemiologic investigation.Setting Urban inner-city hospital.Patients Six persons who received Babesia microti-infected blood components from a donor,Main Outcome Measure Diagnosis and successful therapy of babesiosis following transfusion.Results Six individuals (1 adult, 1 child, and 4 neonates) were exposed to products from a single blood donation by an asymptomatic Babesia-infected donor. Three of the 6 exposed patients became parasitemic, Polymerase chain reaction testing, animal inoculation studies, and indirect immunofluorescent antibody testing were used to confirm the presence of Babesia microti in the donor's blood and to establish the presence of infection in 3 of the 6 recipients, The 3 infected recipients and 1 additional recipient were treated without incident.Conclusion Physicians should consider babesiosis in the differential diagnosis of a febrile hemolytic disorder after blood transfusion. Prompt diagnosis is important since babesiosis is responsive to antibiotic therapy and, untreated, can be a fatal disease in certain risk groups.