Analysis of the articular cartilage T1 and T2 relaxation times changes after ACL reconstruction in injured and contralateral knees and relationships with bone shape
Analysis of the articular cartilage T1 and T2 relaxation times changes after ACL reconstruction in injured and contralateral knees and relationships with bone shape
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DOI：
10.1002/jor.23398
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发表时间：
2017-03-01
影响因子：
2.8
通讯作者：
Li, Xiaojuan
中科院分区：
文献类型：
--
作者：
Pedoia, Valentina;Su, Favian;Li, Xiaojuan
本研究的目的有两个：（1）评价重建和完整对侧膝关节ACL重建（ACLR）后6个月和12个月软骨T-1和T-2的纵向变化，目的是验证对侧膝关节作为纵向研究中内部对照的作用;（2）探讨ACLR后12个月内T-1、T-2变化与骨形态的关系。计算40例ACL损伤患者和15例健康对照者双膝的T-1和T-2软骨松弛时间和基于3D MRI的胫骨和股骨统计形状建模（SSM）。ACL受试者在损伤后8.4 ± 6.4周（ACLR前2.4 ± 3.7周）、ACLR后6个月和12个月进行扫描。采用线性混合模型评估T-1和T-2值的纵向变化，并计算骨形状与T-1和T-2值纵向变化之间的偏相关系数。ACLR后6个月，在重建膝关节和对侧膝关节中观察到T-1和T-2值的纵向显著增加。胫骨形状特征，与内侧平台的高度和宽度，被观察到与软骨T-1和T-2进展重建膝关节。我们的研究结果表明，在纵向ACL研究中，应谨慎考虑将对侧膝关节作为内部对照，基于3D MRI的SSM可能作为ACL撕裂后发生创伤后加速软骨退化和潜在骨关节炎风险患者早期分层的成像生物标志物。(c)2016骨科研究学会。由威利期刊公司出版J Orthop Res 35：707-717，2017。
The objectives of this study were twofold: (1) to evaluate the longitudinal change in cartilage T-1 and T-2 6- and 12-months after ACL reconstruction (ACLR) in both reconstructed and intact contralateral knees with the aim of validating the role of the contralateral knee as an internal control in longitudinal studies; (2) to explore relationships between bone shape at the time of injury and the progression of T-1 and T-2 over 12-months after ACLR. T-1 and T-2 cartilage relaxation times and 3D MRI-based statistical shape modeling (SSM) of tibia and femur were computed for both knees of forty ACL-injured patients and 15 healthy controls. ACL subjects were scanned 8.4 +/- 6.4 weeks after injury (2.4 +/- 3.7 weeks prior to ACLR), 6- and 12-months after ACLR. Longitudinal changes in T-1 and T-2 values were assessed using linear mixed model, and partial correlation coefficients were calculated between bone shape and longitudinal changes in T-1 and T-2 values. Significant longitudinal increases in T-1 and T-2 values were observed in reconstructed and contralateral knees 6-months after ACLR. Tibial bone shape features, associated with the medial plateau height and width, were observed to be correlated with cartilage T-1 and T-2 progression in reconstructed knees. Our results suggest that caution should be used in considering contralateral knee as internal controls in longitudinal ACL studies and 3D MRI-based-SSM might serve as an imaging biomarker for the early stratification of patients at risk for developing post-traumatic accelerated cartilage degeneration and potentially osteoarthritis after ACL tear. (c) 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:707-717, 2017.