Ethical and Practical Issues Associated With the Possibility of Using Controlled Human Infection Trials in Developing a Hepatitis C Virus Vaccine.
Ethical and Practical Issues Associated With the Possibility of Using Controlled Human Infection Trials in Developing a Hepatitis C Virus Vaccine.
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与使用受控人体感染试验开发丙型肝炎病毒疫苗的可能性相关的伦理和实践问题。
DOI：
10.1093/cid/ciaa640
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Sugarman,Jeremy
中科院分区：
文献类型：
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作者：
Cox,Andrea;Sulkowski,Mark;Sugarman,Jeremy
尽管存在针对丙型肝炎病毒（HCV）的既定治疗方法，但可以说需要更有效的预防感染手段，如疫苗，以帮助降低全球发病率和死亡率。鉴于在感染风险较高的人群中开发此类疫苗的预期挑战，受控人类感染研究似乎是HCV疫苗开发的一种有希望的潜在方法，但它们引起了重大的伦理和实践问题。在这篇文章中，我们描述了一些挑战的可能性，使用控制人类感染的研究，以加速丙型肝炎疫苗的发展。在规划和实施这些研究之前，需要进一步审议相关的伦理和实际问题。
Despite the existence of established treatments for hepatitis C virus (HCV), more effective means of preventing infection, such as a vaccine, are arguably needed to help reduce substantial global morbidity and mortality. Given the expected challenges of developing such a vaccine among those at heightened risk of infection, controlled human infection studies seem to be a promising potential approach to HCV vaccine development, but they raise substantial ethical and practical concerns. In this article, we describe some of the challenges related to the possibility of using controlled human infection studies to accelerate HCV vaccine development. The related ethical and practical concerns require further deliberation before such studies are planned and implemented.