Linking peripheral IL-6, IL-1β and hypocretin-1 with cognitive impairment from major depression
Linking peripheral IL-6, IL-1β and hypocretin-1 with cognitive impairment from major depression
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外周IL-6、IL-1β和下丘脑分泌素-1与重度抑郁症认知障碍的关系
DOI：
10.1016/j.jad.2020.08.024
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发表时间：
2020-12-01
影响因子：
6.6
通讯作者：
Huang, Manli
中科院分区：
文献类型：
--
作者：
Jin, Kangyu;Lu, Jing;Huang, Manli
背景：认知功能障碍长期以来一直是重度抑郁症（MDD）患者面临的挑战，近年来，下丘脑分泌素和炎症与认知功能有关。然而，有限的研究已经全面评估了它们与重度抑郁症认知障碍的关系。方法：共招募100例重度抑郁症患者和100例健康对照（HC）。分别用HAMD、HAMA和MCCB量表进行测试。采用酶联免疫吸附试验（ELISA）测定血浆中选定炎症因子（IL-1 β、IL-6和tnf - α）和下丘脑泌素-1的水平。通过相关分析探讨血浆中各因子水平与临床表现的关系。结果：与HC相比，MDD患者除工作记忆外，MCCB各亚域均存在认知障碍。MDD患者IL-6、IL-1 β和下丘脑泌素-1水平高于HC。此外，联合组IL-1 β水平与整体认知功能呈负相关。下丘脑泌素-1与重度抑郁症患者的社会认知障碍呈正相关。MDD患者血浆下丘脑泌素-1水平与HAMA量表之间也存在负相关。局限性：该研究是横断面的，因此限制了因果推断，并且样本量相对较小。MDD没有基于特征的子类别。结论：IL-1 β、IL-6和下丘脑分泌素-1是MDD病理的潜在因素。下丘脑泌素-1可能参与缓解焦虑的生物学机制。因此，下丘脑泌素-1在探讨重度抑郁症患者社会认知障碍的病理机制中可能具有重要意义。总之，本研究为探索抑郁症的认知障碍提供了新的见解。
Background: Cognitive impairment has long challenged the patients with major depressive disorder (MDD), hypocretins and inflammation have recently been implicated in cognitive function. However, limited studies have compressively assessed their associations with cognitive impairment in MDD.Methods: A total of 100 MDD patients and 100 healthy controls (HC) were recruited for this study. They were tested with HAMD, HAMA, and MCCB scales. The plasma level of selected inflammatory factors (IL-1 beta, IL-6, and TNF-alpha) and hypocretin-1 were determined using enzyme-linked immunosorbent assay (ELISA). Correlation analysis was performed to explore the relationship between the plasma level of the factors and clinical performances.Results: Patients with MDD showed cognitive impairment in each MCCB subdomain except working memory compared with HC. The levels of IL-6, IL-1 beta and hypocretin-1 in MDD patients were higher than HC. Besides, IL-1 beta levels was negatively correlated with overall cognitive function in the combined group. Hypocretin-1 was positively correlated with socially cognitive impairment in MDD patients. A negative correlation between plasma hypocretin-1 levels and HAMA scales was also observed in MDD patients.Limitation: The study was cross-sectional, thereby limiting causal inference, and had a relatively small sample size. There are no subcategories for MDD based on characteristics.Conclusion: IL-1 beta, IL-6 and Hypocretin-1 were reported as potential factors involved in MDD pathology. Hypocretin-1 could contribute to the biological mechanisms of anxiety relief. Hypocretin-1, therefore, may be important in exploring the pathological mechanisms of social cognitive impairment in MDD patients. Conclusively, this study provides new insights for exploring cognitive impairment in depression.