Approaches Mediating Oxytocin Regulation of the Immune System.
Approaches Mediating Oxytocin Regulation of the Immune System.
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接近介导免疫系统调节的催产素调节。
DOI：
10.3389/fimmu.2016.00693
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发表时间：
2016
影响因子：
7.3
通讯作者：
Wang YF
中科院分区：
文献类型：
--
作者：
Li T;Wang P;Wang SC;Wang YF
下丘脑神经内分泌系统主要由调节垂体激素分泌的神经结构组成，被认为是免疫系统的高级调节中心。下丘脑-神经垂体系统（hypothalamo-neurophysial system，HNS）是近年来发现的神经内分泌-免疫网络的重要组成部分，其中催产素（oxytocin，OT）分泌系统（oxytocin，OSS）起着重要作用。OSS由位于视上核、室旁核及其附属核团和相关结构的OT神经元组成，能整合神经、内分泌、代谢和免疫信息，在免疫系统的发育和功能中起着关键作用。OSS能促进胸腺和骨髓的发育，发挥免疫监视作用，增强免疫防御能力，维持免疫稳态。相应地，OT可以抑制炎症，发挥抗炎样作用，促进伤口愈合和再生，并抑制应激相关的免疫紊乱。在此过程中，OSS可通过激活OT受体或间接调节下丘脑-垂体-免疫轴和自主神经系统的活动，释放OT直接作用于免疫系统。然而，我们对OSS在免疫系统的神经内分泌调节中的作用的认识在很大程度上是不完整的，特别是它与其他下丘脑-垂体-免疫轴以及与OSS共存的HNS中的加压素分泌系统的关系。此外，OSS和外周产生的OT在免疫调节中的关系仍不清楚，特别是已知引起T细胞对垂体激素的中枢免疫自身耐受的胸腺内OT。在这项工作中，我们提供了一个简短的审查，目前的知识的OSS调节免疫系统的功能和潜在的方法，介导OSS协调整个神经内分泌免疫网络的活动。
The hypothalamic neuroendocrine system is mainly composed of the neural structures regulating hormone secretion from the pituitary gland and has been considered as the higher regulatory center of the immune system. Recently, the hypothalamo-neurohypophysial system (HNS) emerged as an important component of neuroendocrine–immune network, wherein the oxytocin (OT)-secreting system (OSS) plays an essential role. The OSS, consisting of OT neurons in the supraoptic nucleus, paraventricular nucleus, their several accessory nuclei and associated structures, can integrate neural, endocrine, metabolic, and immune information and plays a pivotal role in the development and functions of the immune system. The OSS can promote the development of thymus and bone marrow, perform immune surveillance, strengthen immune defense, and maintain immune homeostasis. Correspondingly, OT can inhibit inflammation, exert antibiotic-like effect, promote wound healing and regeneration, and suppress stress-associated immune disorders. In this process, the OSS can release OT to act on immune system directly by activating OT receptors or through modulating activities of other hypothalamic–pituitary–immune axes and autonomic nervous system indirectly. However, our understandings of the role of the OSS in neuroendocrine regulation of immune system are largely incomplete, particularly its relationship with other hypothalamic–pituitary–immune axes and the vasopressin-secreting system that coexists with the OSS in the HNS. In addition, it remains unclear about the relationship between the OSS and peripherally produced OT in immune regulation, particularly intrathymic OT that is known to elicit central immunological self-tolerance of T-cells to hypophysial hormones. In this work, we provide a brief review of current knowledge of the features of OSS regulation of the immune system and of potential approaches that mediate OSS coordination of the activities of entire neuroendocrine–immune network.