Antibiotic–cell‐penetrating peptide conjugates targeting challenging drug‐resistant and intracellular pathogenic bacteria
Antibiotic–cell‐penetrating peptide conjugates targeting challenging drug‐resistant and intracellular pathogenic bacteria
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DOI：
10.1111/cbdd.13930
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发表时间：
2021-07
影响因子：
3
通讯作者：
Samantha M. Zeiders;J. Chmielewski
中科院分区：
文献类型：
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作者：
Samantha M. Zeiders;J. Chmielewski
未能治疗日常细菌感染是目前的一个威胁，因为病原体正在寻找新的方法，通过耐药机制和细胞内庇护来阻挠抗生素，从而使目前的抗生素策略无效。细胞穿透肽(CPP)提供了一种方法来改进已经被批准使用的抗生素。通过抗生素与CPP的共同给药和结合，观察到通过替代和/或附加的抗感染作用模式改善了蓄积性和选择性。在此，我们综述了这种抗生素细胞穿透肽策略在对抗敏感和耐药病原体方面的最新进展。我们仔细研究了已经增强的特定抗生素，在某些情况下，这些抗生素被重新用作广谱药物。通过在抗生素中添加和结合细胞穿透性多肽，增加了对哺乳动物和/或细菌膜的渗透，并扩大了细菌选择性的范围。
The failure to treat everyday bacterial infections is a current threat as pathogens are finding new ways to thwart antibiotics through mechanisms of resistance and intracellular refuge, thus rendering current antibiotic strategies ineffective. Cell‐penetrating peptides (CPPs) are providing a means to improve antibiotics that are already approved for use. Through coadministration and conjugation of antibiotics with CPPs, improved accumulation and selectivity with alternative and/or additional modes of action against infections have been observed. Herein, we review the recent progress of this antibiotic–cell‐penetrating peptide strategy in combatting sensitive and drug‐resistant pathogens. We take a closer look into the specific antibiotics that have been enhanced, and in some cases repurposed as broad‐spectrum drugs. Through the addition and conjugation of cell‐penetrating peptides to antibiotics, increased permeation across mammalian and/or bacterial membranes and a broader range in bacterial selectivity have been achieved.