Anti-inflammatory activity of amylin and CGRP in different experimental models of inflammation
Anti-inflammatory activity of amylin and CGRP in different experimental models of inflammation
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DOI：
10.1016/0024-3205(95)02100-w
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发表时间：
1995-01-01
期刊：
影响因子：
6.1
通讯作者：
Amico-Roxas, Matilde
中科院分区：
文献类型：
--
作者：
Clementi, Giuseppe;Caruso, Antonina;Amico-Roxas, Matilde
在不同的炎症模型中研究胰淀素的抗炎活性，并与CGRP进行比较。两种多肽均对巴豆油所致小鼠耳部水肿和醋酸所致大鼠腹膜炎有抑制作用。在两种模型中，CGRP均比胰淀素更有效。CGRP 8-37片段预处理可阻断两种多肽对巴豆油耳部水肿的抗炎活性。对血清素所致大鼠足跖水肿及葡聚糖所致大鼠皮肤血浆蛋白外渗无抗炎作用。我们的研究结果表明，胰淀素仅在以血管成分为特征的炎症模型中发挥抗炎活性。这种作用似乎是由CGRP受体的参与介导的。
The anti-inflammatory activity of amylin was studied in different models of inflammation, and compared to that of CGRP. Both peptides were active against mouse ear oedema induced by croton oil and acetic acid-induced peritonitis in the rat. CGRP was more potent than amylin in both models. Pretreatment with CGRP 8-37 fragment blocked the anti-inflammatory activity of both peptides in croton oil ear oedema. No anti-inflammatory activity was evidenced against serotonin-induced rat paw oedema and plasma protein extravasation induced by dextran in rat skin. Our results suggest that amylin exerts anti-inflammatory activity only in inflammatory models characterized by a vascular component. This effect appears to be mediated by the involvement of CGRP receptors.