Genitourinary toxicity after permanent iodine-125 seed implantation: The nationwide Japanese prostate cancer outcome study of permanent iodine-125 seed implantation (J-POPS)
Genitourinary toxicity after permanent iodine-125 seed implantation: The nationwide Japanese prostate cancer outcome study of permanent iodine-125 seed implantation (J-POPS)
复制标题
DOI：
10.1016/j.brachy.2019.03.007
复制
发表时间：
2019-07-01
期刊：
影响因子：
1.9
通讯作者：
Fukushima, Masanori
中科院分区：
文献类型：
--
作者：
Tanaka, Nobumichi;Yorozu, Atsunori;Fukushima, Masanori
目得：本研究的目的是评价日本一项全国性前瞻性队列研究中接受永久性粒子植入（PI）治疗的前列腺癌患者的急性和晚期泌尿生殖系统（GU）毒性，并阐明与GU毒性相关的因素。在入组本研究的2，354例患者中，在PI后3、12、24和36个月对2，339例患者进行了GU毒性评价。为了阐明预测急性和晚期不良事件通用术语标准2级或更高（等级>= 2）GU毒性的独立因素，进行多变量逻辑回归分析。关于急性尿潴留（AUR），发病率和AUR的恢复率估计使用Kaplan-Meier curve.RESULTS：约53%的患者与PI单独治疗和42%的患者与PI治疗和外照射联合治疗显示尿频/尿急在3个月。多变量分析显示，年龄、前列腺体积、治疗前国际前列腺症状评分、饮酒状况和PI是急性GU毒性≥ 2级的独立预测因素。在所有患者中，53例（2.3%）患有AUR，49例（92.5%）从AUR中恢复，中位时间为4.3个月，在follow-up periods.CONCLUSIONS：GU毒性的结果在日本患者接受低剂量率近距离放射治疗是可以接受的，与以前报道的美国患者。在急性期，单独使用PI治疗的患者GU毒性的发生率明显高于接受PI和外照射联合治疗的患者。(C)2019年美国近距离放射治疗协会。爱思唯尔公司出版All rights reserved.
PURPOSE: The purpose of this study was to evaluate acute and late genitourinary (GU) toxicity and to elucidate factors associated with GU toxicity in patients with prostate cancer treated with permanent seed implantation (PI) enrolled in a nationwide prospective cohort study in Japan.METHODS AND MATERIALS: Of 2,354 patients enrolled in this study, GU toxicity was evaluated in 2,339 patients at 3, 12, 24, and 36 months after PI. To elucidate independent factors predictive of acute and late Common Terminology Criteria for Adverse Events Grade 2 or higher (Grade >= 2) GU toxicity, multivariate logistic regression analyses were carried out. Regarding acute urinary retention (AUR), the incidence rate and the recovery rate for AUR were estimated using the Kaplan-Meier curve.RESULTS: Approximately 53% of the patients treated with PI alone and 42% of those treated with combination therapy with PI therapy and external beam radiation therapy showed urinary frequency/urgency at 3 months. The multivariate analysis revealed that age, prostate volume, pretreatment international prostate symptom score, drinking status, and PI were independent predictors of acute GU toxicity Grade >= 2. Of all patients, 53 (2.3%) suffered from AUR, and 49 (92.5%) recovered from AUR with a median time of 4.3 months during the followup period.CONCLUSIONS: The results of GU toxicity in Japanese patients who underwent low-dose-rate brachytherapy were acceptable and comparable to those previously reported in U.S. patients. The patients treated with PI alone showed a significantly higher incidence rate of GU toxicity than did those undergoing combination therapy with PI and external beam radiation therapy in the acute phase. (C) 2019 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.