Tibial cancellous bone changes in patients with knee osteoarthritis. A short-term longitudinal study using Fractal Signature Analysis
Tibial cancellous bone changes in patients with knee osteoarthritis. A short-term longitudinal study using Fractal Signature Analysis
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DOI：
10.1016/j.joca.2005.01.007
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发表时间：
2005-06-01
影响因子：
7
通讯作者：
Buckland-Wright, C
中科院分区：
文献类型：
--
作者：
Messent, EA;Ward, RJ;Buckland-Wright, C
目的：量化膝内侧间室骨关节炎 (OA) 患者 24 个月内胫骨松质骨的变化，分为缓慢或可检测到的关节间隙狭窄 (JSN) 患者。方法。 40 名患者 (F:26) 在基线和 24 个月时获得了数字化宏观放射线照片 (4 X)，并通过最小内侧间室关节间隙宽度 (JSW) 的计算机测量将其细分为慢 JSN（< 0.2 毫米/年，n = 66）或可检测 JSN（≥ 0.2 毫米/年，n = 14）以及基线时平均（范围）JSW 为 3.89 的患者分别为 (1.66-5.48) 毫米和 3.73 (2.49-5.74) 毫米。分形特征分析测量了四个感兴趣区域 (ROI) 的骨结构纵向变化：内侧和外侧软骨下 (Sc) 和关节下 (Sa) 区域。结果：慢速组和可检测组的平均（范围）JSN 分别为 0.01 (-0.31-0.18) 毫米/年和 0.44 (0.20-1.01) 毫米/年。 24 个月内，两组所有 ROI 在大多数小梁尺寸（垂直：0.36-1.14 毫米；水平：0.36-1.14 毫米，不包括外侧 Sa 区域）处的分形维数 (FD) 均显着 (P < 0.05) 下降。除了 Sa 区域内的少数小梁尺寸外，组间没有差异，其中可检测的 JSN 组与慢速 JSN 组相比，FD 显着 (P < 0.05) 下降更大（内侧：水平尺寸 0.54-0.72 mm、1.02-1.08 mm；外侧：垂直尺寸 0.90-1.02 mm）。结论：所有内侧间室 OA 的膝关节均发生骨丢失。垂直和水平小梁FD的减少与与损失相关的小梁数量的减少一致。骨质流失的模式与 JSN 缓慢且可检测到的膝盖相似。 (C) 2005 年国际骨关节炎研究协会。由爱思唯尔有限公司出版。保留所有权利。
Objective: To quantify tibial cancellous bone changes over 24 months in patients with medial compartment knee osteoarthritis (OA) subdivided into those with slow or detectable joint space narrowing (JSN).Method. Digitised macroradiographs (4 X) were obtained at baseline and 24 months from 40 patients (F:26) and subdivided by computerised measurement of minimum medial compartment joint space width (JSW) into those with slow JSN (< 0.2 mm/year, n = 66) or detectable JSN ( ! 0.2 mm/year, n = 14) and who had a mean (range) JSW at baseline of 3.89 (1.66-5.48) mm and 3.73 (2.49-5.74) mm, respectively. Fractal Signature Analysis measured longitudinal change in bone structure at four regions of interest (ROI): medial and lateral subchondral (Sc) and subarticular (Sa) regions.Results: Mean (range) JSN for slow and detectable groups was 0.01 (-0.31-0.18) mm/year and 0.44 (0.20-1.01)mm/year, respectively. All ROIs in both groups had significant (P < 0.05) decrease in fractal dimension (FD) at most trabecular sizes (vertical: 0.36-1.14 mm; horizontal: 0.36-1.14 mm, excluding the lateral Sa region) over 24 months. There were no between-group differences except at a few trabecular sizes within the Sa regions where the detectable JSN group had significantly (P < 0.05) greater decrease in FD compared to the slow JSN group (medial: horizontal sizes 0.54-0.72 mm, 1.02-1.08 mm; lateral: vertical sizes 0.90-1.02 mm).Conclusion: Bone loss occurred in all knees with medial compartment OA. Decrease in FD of vertical and horizontal trabeculae was consistent with decrease in trabecular number associated with loss. The pattern of bone loss was similar in knees with slow and detectable JSN. (C) 2005 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.