Patterns of recurrence and prognosis in pathologic stage I and II Merkel cell carcinoma: A multicenter, retrospective cohort analysis.
Patterns of recurrence and prognosis in pathologic stage I and II Merkel cell carcinoma: A multicenter, retrospective cohort analysis.
复制标题
病理学 I 期和 II 期 Merkel 细胞癌的复发和预后模式：多中心、回顾性队列分析。
DOI：
10.1016/j.jaad.2022.05.019
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发表时间：
2023
影响因子：
13.8
通讯作者：
Beasley,G
中科院分区：
文献类型：
--
作者：
Tieniber,AndrewD;Shannon,AdrienneB;Carr,MichaelJ;Sun,James;Landa,Karenia;Baecher,KirstenM;Lynch,Kevin;Bartels,HarrisonG;Panchaud,Robyn;Lowe,MichaelC;Slingluff,CraigL;Jameson,MarkJ;Tsai,KennethY;Faries,MarkB;Beasley,G
梅克尔细胞癌（MCC）是一种罕见的神经内分泌皮肤肿瘤，具有局部和远处扩散的高风险。尽管由于最近NCCN的推荐，前哨淋巴结活检（SLNB）的使用有所增加，但关于具有完全病理淋巴结微分期的临床局限性MCC患者的结果仍然缺乏数据。在MCC中，疾病复发是一个不良的预后迹象，努力预防复发可能会改善生存。这项多中心研究旨在检查病理I期和II期MCC患者中的57例患者，肿瘤和治疗特征，并确定58例复发和患者生存模式。这些数据有助于为局部MCC的监测战略提供信息。来自美国癌症联合委员会（AJCC）第8版6个中心的6061名成年患者，从2005年到2020年鉴定了62例病理I-II期MCC。研究纳入要求63例患者接受微转移性肿瘤阴性SLNB切除术。在分析和比较I-II期65例患者时，考虑了各种患者、64种肿瘤和治疗特征（补充表1）。分类变量和连续变量66分别采用Pearson χ 2检验和Wilcoxon秩和检验进行单因素分析。根据Cox比例风险回归分析确定67例全部位复发的预测因子；采用Kaplan-Meier法分析68例无病生存期（DSS），采用分层对数秩检验进行比较。70
To the Editor: Merkel cell carcinoma (MCC) is a rare neuroendocrine skin tumor with a high risk 52 of local and distant spread. Despite the increase in sentinel lymph node biopsy (SLNB) 53 utilization as a result of recent NCCN recommendations, there remains a paucity of data 54 regarding outcomes in clinically localized MCC patients with complete pathologic nodal 55 microstaging. 1 In MCC, disease relapse is a poor prognostic sign and efforts to prevent 56 recurrences may result in improved survival. 2 This multi-center study was designed to examine 57 patient, tumor, and treatment characteristics among pathologic stage I and II MCC patients and 58 characterize patterns of recurrence and patient survival. These data can help inform surveillance 59 strategies for localized MCC. 6061 Adult patients from six centers with American Joint Committee on Cancer (AJCC) 8th edition 62 pathologic stage I-II MCC from 2005 to 2020 were identified. Study inclusion required patients to 63 undergo resection with SLNB that was negative for micrometastatic disease. Various patient, 64 tumor, and treatment characteristics were considered in the analysis and compared in stage I-II 65 patients (Supplemental Table 1). Univariate analysis for categorical and continuous variables 66 was performed using Pearson’s χ² test and Wilcoxon rank-sum test, respectively. Predictors of 67 all-site recurrence were determined based on Cox proportional hazard regression analyses; 68 disease free survival (DSS) was analyzed using the Kaplan-Meier method and compared using 69 the stratified log-rank test. 70