Visible Light-Mediated Polymerization-Induced Self-Assembly in the Absence of External Catalyst or Initiator.
Visible Light-Mediated Polymerization-Induced Self-Assembly in the Absence of External Catalyst or Initiator.
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DOI：
10.1021/acsmacrolett.6b00235
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发表时间：
2016-04
影响因子：
5.8
通讯作者：
Jonathan Yeow;Odilia R. Sugita;C. Boyer
中科院分区：
文献类型：
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作者：
Jonathan Yeow;Odilia R. Sugita;C. Boyer
我们报告使用可见光介导的RAFT分散聚合在没有外部催化剂或引发剂，根据聚合诱导的自组装（比萨）机制产生不同形态的纳米粒子。衍生自4-氰基-4-（（十二烷基硫基硫代羰基）硫基）戊酸（CDTPA）RAFT试剂的POEGMA大分子链转移剂（大分子CTA）可在蓝光（460 nm，0.7 mW/cm 2）或绿色（530 nm，0.7 mW/cm 2）下活化，并在乙醇分散条件下同时充当自由基引发剂、链转移剂和颗粒稳定剂。特别是，蠕虫状胶束的形成很容易监测聚合过程中的反应粘度的增加，这种方法被证明是特别强大的不同的反应参数，如不同分子量的macro-CTA。有趣的是，在高单体转化率下，取决于所采用的光的波长形成不同的形态，这可能是由于不同程度的聚合控制。最后，在原位封装的模型疏水性药物，尼罗红，被证明，这表明应用程序的合成纳米颗粒的药物输送应用程序的简易过程。
We report the use of visible light to mediate a RAFT dispersion polymerization in the absence of external catalyst or initiator to yield nanoparticles of different morphologies according to a polymerization-induced self-assembly (PISA) mechanism. A POEGMA macro-chain transfer agent (macro-CTA) derived from a 4-cyano-4-((dodecylsulfanylthiocarbonyl)sulfanyl)pentanoic acid (CDTPA) RAFT agent can be activated under blue (460 nm, 0.7 mW/cm2) or green (530 nm, 0.7 mW/cm2) light and act simultaneously as a radical initiator, chain transfer agent, and particle stabilizer under ethanolic dispersion conditions. In particular, the formation of worm-like micelles was readily monitored by the increase of reaction viscosity during the polymerization; this method was shown to be particularly robust to different reaction parameters such as macro-CTAs of varying molecular weight. Interestingly, at high monomer conversion, different morphologies were formed depending on the wavelength of light employed, which may be due to differing degrees of polymerization control. Finally, the in situ encapsulation of the model hydrophobic drug, Nile Red, was demonstrated, suggesting applications of this facile process for the synthesis of nanoparticles for drug delivery applications.