Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells
Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells
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DOI：
10.1016/j.ceb.2009.04.009
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发表时间：
2009-06-01
影响因子：
7.5
通讯作者：
Filipowicz, Witold
中科院分区：
文献类型：
--
作者：
Chekulaeva, Marina;Filipowicz, Witold
MicroRNAs(MiRNAs)是一种长度为20个核苷酸到24个核苷酸的非编码RNA，在动植物中作为基因表达的转录后调节因子。在哺乳动物中，预计超过50%的mRNAs是miRNA介导的调控对象，但这种调控的机制方面尚不完全清楚，不同的研究得出了经常相互矛盾的结果。MiRNAs可以影响mRNAs的翻译和稳定性。在这篇报告中，我们回顾了目前在理解miRNAs如何在动物中执行这些作用方面的进展，并讨论了关于miRNA功能的不同模式的一些争议。
MicroRNAs (miRNAs) are 20-nt-long to 24-nt-long noncoding RNAs acting as post-transcriptional regulators of gene expression in animals and plants. In mammals, more than 50% of mRNAs are predicted to be the subject of miRNA-mediated control but mechanistic aspects of the regulation are not fully understood and different studies have produced often-contradictory results. miRNAs can affect both the translation and stability of mRNAs. In this report, we review current progress in understanding how miRNAs execute these effects in animals and we discuss some of the controversies regarding different modes of miRNA function.