Screening for Myositis Antibodies in Idiopathic Interstitial Lung Disease
Screening for Myositis Antibodies in Idiopathic Interstitial Lung Disease
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DOI：
10.1007/s00408-019-00212-9
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发表时间：
2019-06-01
期刊：
影响因子：
5
通讯作者：
Shapera, Shane
中科院分区：
文献类型：
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作者：
Fidler, Lee;Doubelt, Irena;Shapera, Shane
目的国际指南建议在评估特发性间质性肺病（ILD）患者时筛查具有自身抗体的结缔组织病（CTD）。特发性炎症性肌炎包括用肌炎抗体（MA）诊断的CTD亚组，通常表现为ILD。我们的目的是评估MA筛查在特发性ILD.MethodsA回顾性分析的患者与特发性ILD的三级中心ILD诊所谁进行了筛选MA。排除已知或疑似CTD的患者。描述性统计，单因素分析和多因素Logistic回归被用来检测MA和患者的patients.ResultsOf 360例患者，165符合纳入标准和44（26.7%）被确定为MA之间的关联。14例患者（8.5%）因MA筛查而诊断发生变化。多变量logistic回归分析确定MA的存在与当前吸烟[OR 6.87（1.65-28.64），p=0.008]和弥散能力相关。
PurposeInternational guidelines recommend screening for connective tissue disease (CTD) with autoantibodies when evaluating patients with idiopathic interstitial lung disease (ILD). Idiopathic inflammatory myositis comprises of a subgroup of CTD diagnosed with myositis antibodies (MA), often presenting with ILD. Our aim was to evaluate the utility of MA screening in patients with idiopathic ILD.MethodsA retrospective analysis was conducted on patients referred with idiopathic ILD to a tertiary centre ILD clinic who were screened for MA. Patients with known or suspected CTD were excluded. Descriptive statistics, univariate analysis and multivariable logistic regression were used to detect associations between MA and patient characteristics.ResultsOf 360 patients, 165 met inclusion criteria and 44 (26.7%) were identified to have MA. Fourteen patients (8.5%) had a change in diagnosis as a result of MA screening. Multivariable logistic regression identified the presence of MA to be associated with current smoking [OR 6.87 (1.65-28.64), p=0.008] and a diffusing capacity of