Immunohistochemical expression of SHH, PTC, SMO and GLI1 in glandular odontogenic cysts and dentigerous cysts.
Immunohistochemical expression of SHH, PTC, SMO and GLI1 in glandular odontogenic cysts and dentigerous cysts.
复制标题
牙源性腺囊肿和含牙囊肿中 SHH、PTC、SMO 和 GLI1 的免疫组织化学表达。
DOI：
10.1111/j.1601-0825.2010.01697.x
复制
发表时间：
2010
期刊：
影响因子：
3.8
通讯作者：
Z. Chen
中科院分区：
文献类型：
--
作者：
L. Zhang;Z. Sun;X. M. Chen;Z. Chen
目的
目的研究声刺猬（SHH）信号通路在腺性牙源性囊肿（GOCs）和含牙囊肿（DCs）中的表达。
材料和方法
免疫组化染色SHH，patched（PTC），smoothened（SMO），和转录因子GLI1在12个GOCs标本和20个DC进行了研究。
结果
在GOCs和DC中，SHH、PTC、SMO和GLI1的免疫反应性在上皮细胞质中检测到。SHH信号通路的每个基因在囊肿的上皮衬里中以相似的模式表达。SHH、PTC、SMO和GLI1在上皮细胞中的表达明显高于上皮下成纤维细胞（P < 0.01）。不同类型囊肿的上皮衬里标记指数之间无统计学差异。
结论
研究结果表明，SHH信号通路的蛋白质主要位于GOCs和DC的上皮成分内。SHH信号通路可能在上皮衬里形成中发挥作用。
OBJECTIVE
To investigate expression of the sonic hedgehog (SHH) signaling pathway components in glandular odontogenic cysts (GOCs), and dentigerous cysts (DCs).
MATERIALS AND METHODS
Immunohistochemical staining for SHH, patched (PTC), smoothened (SMO), and the transcriptional factor GLI1 were investigated in the 12 GOCs specimens and 20 DCs.
RESULTS
In GOCs and DCs, immunoreactivity for SHH, PTC, SMO, and GLI1 were detected in the epithelial cytoplasm. Each of the genes of the SHH signaling pathway was expressed in similar patterns in the epithelial lining of the cysts. The expression of SHH, PTC, SMO, and GLI1 was significantly higher in epithelia than that of subepithelial fibroblasts (P < 0.01). No statistical difference among the labeling index of the epithelial lining among the different cyst types could be revealed.
CONCLUSIONS
The findings suggest that the proteins of the SHH signaling pathway are predominantly located within the epithelial components of GOCs and DCs. SHH signaling pathway may play a role in epithelial lining formation.
影响因子：
4.6
作者：
H. R. Dassule;P. Lewis;M. Bei;R. Maas;Andy McMahon
通讯作者：
H. R. Dassule;P. Lewis;M. Bei;R. Maas;Andy McMahon
影响因子：
50.3
作者：
Romer, JT;Kimura, H;Curran, T
通讯作者：
Curran, T