GABA+ levels in postmenopausal women with mild-to-moderate depression: A preliminary study.
GABA+ levels in postmenopausal women with mild-to-moderate depression: A preliminary study.
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患有轻度至中度抑郁症的绝经后女性的 GABA+ 水平：初步研究
DOI：
10.1097/md.0000000000004918
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发表时间：
2016-09
期刊：
影响因子：
1.6
通讯作者：
Edden RA
中科院分区：
文献类型：
--
作者：
Wang Z;Zhang A;Zhao B;Gan J;Wang G;Gao F;Liu B;Gong T;Liu W;Edden RA
越来越多的人认识到GABA能系统的改变与抑郁症的病理生理学有关。本研究旨在利用磁共振波谱（1H-MRS）技术探讨绝经后抑郁症患者前扣带/内侧前额叶皮质（ACC/mPFC）和后扣带皮质（PCC）γ-氨基丁酸（GABA）水平。19名绝经后抑郁症妇女和13名健康对照者参加了这项研究。所有受试者均使用“MEGA点分辨光谱序列”（MEGA-PRESS）技术进行ACC/mPFC和PCC的1H-MRS。采用17项汉密尔顿抑郁量表（HAMD）评定抑郁程度。使用Gannet程序进行MRS数据的定量。使用单因素方差分析测试患者和对照组GABA+水平的差异。斯皮尔曼相关系数用于评估GABA+水平与HAMD评分以及雌激素水平之间的线性关系。与健康对照组相比，绝经后抑郁症妇女ACC/mPFC中GABA+水平显著降低（P = 0.002）。 ACC/mPFC的17-HAMD/14-HAMA与GABA+水平无显著相关性（P = 0.486; r = 0.170/P = 0.814; r =-0.058）或PCC（P = 0.887; r = 0.035/ P = 0.987; r =-0.004）;患者组GABA+水平与雌激素水平也无显著相关性（ACC/mPFC：P = 0.629，r =-0.018; PCC：P = 0.861，r = 0.043）。绝经后抑郁症患者ACC/mPFC中GABA+水平显著降低，提示GABA能系统功能障碍可能也参与了绝经后抑郁症的发病。
It is increasingly being recognized that alterations of the GABAergic system are implicated in the pathophysiology of depression. This study aimed to explore in vivo gamma-aminobutyric acid (GABA) levels in the anterior cingulate cortex/medial prefrontal cortex (ACC/mPFC) and posterior-cingulate cortex (PCC) of postmenopausal women with depression using magnetic resonance spectroscopy (1H-MRS). Nineteen postmenopausal women with depression and thirteen healthy controls were enrolled in the study. All subjects underwent 1H-MRS of the ACC/mPFC and PCC using the “MEGA Point Resolved Spectroscopy Sequence” (MEGA-PRESS) technique. The severity of depression was assessed by 17-item Hamilton Depression Scale (HAMD). Quantification of MRS data was performed using Gannet program. Differences of GABA+ levels from patients and controls were tested using one-way analysis of variance. Spearman correlation coefficients were used to evaluate the linear associations between GABA+ levels and HAMD scores, as well as estrogen levels. Significantly lower GABA+ levels were detected in the ACC/mPFC of postmenopausal women with depression compared to healthy controls (P = 0.002). No significant correlations were found between 17-HAMD/14-HAMA and GABA+ levels, either in ACC/mPFC (P = 0.486; r = 0.170/P = 0.814; r = −0.058) or PCC (P = 0.887; r = 0.035/ P = 0.987; r = −0.004) in the patients; there is also no significant correlation between GABA+ levels and estrogen levels in patients group (ACC/mPFC: P = 0.629, r = −0.018; PCC: P = 0.861, r = 0.043). Significantly lower GABA+ levels were found in the ACC/mPFC of postmenopausal women with depression, suggesting that the dysfunction of the GABAergic system may also be involved in the pathogenesis of depression in postmenopausal women.