A new role for histone tail modifications in transcription elongation
A new role for histone tail modifications in transcription elongation
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DOI：
10.1101/gad.1628707
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发表时间：
2007-12-15
影响因子：
10.5
通讯作者：
Tamkun, John W.
中科院分区：
文献类型：
--
作者：
Hartzog, Grant A.;Tamkun, John W.
RNA聚合酶II(POL II)在转录基因时面临着许多艰巨的任务。它必须对大量的转录调控因子做出反应，允许对数千个基因进行不同的调控。它必须将其活动与RNA加工事件以及染色质修饰和结构的调节相协调(Sims等人。2004年；Saunders等人。2006)。C-末端结构域(CTD)是POL II最大亚基C末端的一种独特结构，可以协调这些活动(Phatnani和GreenLeaf 2006)。CTD由Y1S2P3T4S5P6S7七肽基序的26至52个拷贝(在酵母中)组成，在转录过程中经历磷酸化和去磷酸化。这些修饰作为POL II在基因转录周期中进展的空间和时间标记。
RNA polymerase II (Pol II) faces a number of daunting tasks while transcribing genes. It must respond to a large array of transcription regulators, permitting distinct regulation of thousands of genes. It must coordinate its activities with RNA processing events and regulators of chromatin modifications and structure (Sims et al. 2004; Saunders et al. 2006). The C-terminal domain (CTD), a unique structure at the C terminus of Pol II’s largest subunit, permits coordination of these activities (Phatnani and Greenleaf 2006). The CTD consists of 26 (in yeast) to 52 (in mice and humans) copies of a heptapeptide motif, Y1S2P3T4S5P6S7, and is subject to phosphorylation and dephosphorylation during transcription. These modifications serve as spatial and temporal markers of Pol II’s progress through a cycle of gene transcription.