Fenofibrate treatment enhances antioxidant status and attenuates endothelial dysfunction in streptozotocin-induced diabetic rats.
Fenofibrate treatment enhances antioxidant status and attenuates endothelial dysfunction in streptozotocin-induced diabetic rats.
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DOI：
10.1155/2010/828531
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发表时间：
2010
影响因子：
--
通讯作者：
Cınar GM
中科院分区：
文献类型：
--
作者：
Olukman M;Sezer ED;Ulker S;Sözmen EY;Cınar GM
糖尿病内皮功能障碍伴随着氧化应激的增加和血管中促炎和炎症介质的上调。过氧化物酶体增殖物激活受体α (PPAR-α)的激活具有抗氧化和抗炎作用。本研究旨在探讨PPAR-α激活剂非诺贝特对链脲佐菌素糖尿病大鼠内皮功能障碍、氧化应激和炎症的影响。糖尿病大鼠服用非诺贝特（150 mg kg - 1 day - 1），连续4周。非诺贝特治疗恢复了受损的内皮依赖性松弛，增加了糖尿病主动脉的基础一氧化氮可用性，提高了红细胞/肝脏超氧化物歧化酶和过氧化氢酶水平，改善了异常的血清/主动脉硫巴比妥酸反应物质，并防止了主动脉髓过氧化物酶升高，而血清总胆固醇和甘油三酯水平没有明显变化。对糖尿病大鼠血清中总同型半胱氨酸水平的降低和肿瘤坏死因子-α水平的升高没有影响。非诺贝特诱导的内皮功能预防似乎与其潜在的抗氧化和抗炎活性有关。
Diabetic endothelial dysfunction is accompanied by increased oxidative stress and upregulated proinflammatory and inflammatory mediators in the vasculature. Activation of peroxisome proliferator-activated receptor-alpha (PPAR-α) results in antioxidant and anti-inflammatory effects. This study was designed to investigate the effect of fenofibrate, a PPAR-α activator, on the endothelial dysfunction, oxidative stress, and inflammation in streptozotocin diabetic rats. Diabetic rats received fenofibrate (150 mg kg−1 day−1) for 4 weeks. Fenofibrate treatment restored the impaired endothelium-dependent relaxation and increased basal nitric oxide availability in diabetic aorta, enhanced erythrocyte/liver superoxide dismutase and catalase levels, ameliorated the abnormal serum/aortic thiobarbituric acid reactive substances, and prevented the increased aortic myeloperoxidase without a significant change in serum total cholesterol and triglyceride levels. It did not affect the decreased total homocysteine level and the increased tumor necrosis factor-α level in the serum of diabetic rats. Fenofibrate-induced prevention of the endothelial function seems to be related to its potential antioxidant and antiinflammatory activity.
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影响因子：
9.8
作者：
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通讯作者：
Couture, Patrick
DOI：
10.1177/107424840300800407
发表时间：
2003-12-01
影响因子：
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影响因子：
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作者：
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通讯作者：
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影响因子：
24
作者：
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通讯作者：
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