EFFECT OF PEPTIDE-YY ON GASTRIC, PANCREATIC, AND BILIARY FUNCTION IN HUMANS
EFFECT OF PEPTIDE-YY ON GASTRIC, PANCREATIC, AND BILIARY FUNCTION IN HUMANS
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DOI：
10.1016/0016-5085(85)90442-1
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发表时间：
1985-01-01
期刊：
影响因子：
29.4
通讯作者：
BLOOM, SR
中科院分区：
文献类型：
--
作者：
ADRIAN, TE;SAVAGE, AP;BLOOM, SR
本文研究了多肽YY(PYY)对人胃和胰胆管分泌的影响。6名健康志愿者分别按0.59pmol.cntdot、0.20pmol.cntdot和0.064 pmol.cNTDot的剂量给药。Kg-1.cntdo.Min-1。在五肽胃泌素的背景刺激下，两个较高的剂量对胃酸和胃酶的输出有显著的抑制作用。中剂量PYY(0.20pmol.cntdo.Kg-1.cntdo.Min-1)，使血浆PYY水平增加27.+-。下午2点导致了90%的+-。18%(平均+-扫描电子显微镜[平均值的标准误差]；P<；0.001)五肽胃泌素增加的胃容量反应的减少。同样，这个剂量的PYY对酸(77%+-)有很大的抑制作用。14%；P<；0.005)和胃酶(96%+-)。22%；P<；0.01)对五肽胃泌素的反应；在2名受试者中，胃酶产量降至基础水平以下。相比之下，最高剂量的PYY(0.62pmol.cntdo.Kg-1.cntdo.在低剂量促胰液素(0.25pmol.cntdot)刺激下，对十二指肠液量、碳酸氢盐、胰酶和胆红素的排出量无显著影响。Kg-1min-1)和CCK-8(0.15pmol.cntdo.Kg-1.cntdo.Min-1。因此，血液循环中的PYY浓度与摄入食物后的浓度相似，会导致胃分泌物显着减少。因此，这种多肽应该被认为是经典肠胃泌素的可能候选者之一。
The effect of peptide YY (PYY) on gastric and pancreatico-biliary secretion was studied in humans. Peptide YY was infused into groups of 6 healthy volunteers at doses of 0.59, 0.20 and 0.064 pmol .cntdot. kg-1 .cntdot. min-1. The 2 higher doses caused a significant suppression of gastric acid and pepsin output during background stimulation with pentagastrin. The middle dose of PYY (0.20 pmol .cntdot. kg-1 .cntdot. min-1) that increased plasma PYY levels by 27 .+-. 2 pM caused a 90% .+-. 18% (mean .+-. SEM [standard error of the mean]; P < 0.001) reduction in the incremental gastric volume response to pentagastrin. Similarly this dose of PYY caused a substantial inhibition of the acid (77% .+-. 14%; P < 0.005) and pepsin (96% .+-. 22%; P < 0.01) response to pentagastrin; in 2 subjects, pepsin output fell to below basal levels. In contrast, the highest dose of PYY (0.62 pmol .cntdot. kg-1 .cntdot. min-1) had no significant influence on duodenal juice volume, output of bicarbonate, trypsin or bilirubin during low-dose stimulation with secretin (0.25 pmol .cntdot. kg-1 min-1) and cholecystokinin-8 (0.15 pmol .cntdot. kg-1 .cntdot. min -1. Thus PYY concentrations in the circulation similar to those seen after the ingestion of food cause a marked reduction in gastric secretion. This peptide should therefore be considered as one of the possible candidates for the classical enterogastrone.