Callosal atrophy in multiple sclerosis is related to cognitive speed
Callosal atrophy in multiple sclerosis is related to cognitive speed
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DOI：
10.1111/ane.12006
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发表时间：
2013-04-01
影响因子：
3.5
通讯作者：
Almkvist, O.
中科院分区：
文献类型：
--
作者：
Bergendal, G.;Martola, J.;Almkvist, O.
李晓明，李晓明，李晓明，李晓明，李晓明。多发性硬化症患者脑胼胝体萎缩与认知速度的关系。神经学报，2013,27(2):281-289。(C) 2012 John Wiley & Sons A/S认知和感觉运动任务中胼胝体面积（CCA）和信息处理速度的长期变化在多发性硬化症（MS）中很少被研究。目的与方法认知（符号数字模态测试，SDMT）、感觉（视觉和听觉反应时间）和运动（手指敲击速度，FT）的信息处理速度；在22例ms患者的基线和9年后的随访中，通过MRI测量，右脑和左手)任务以及听觉半球间转移（言语二分聆听，VDL）与CCA相关，可能的混淆因素包括人口统计学（年龄、性别和教育）、临床（症状发作、持续时间、疾病严重程度）和相对脑容量（RBV）以及T2病变负荷。结果基线CCA越小，SDMT表现越慢。同样，随访时的CCA与随访时不良的SDMT结果相关。此外，CCA的年变化率越高，左耳VDL的表现越差，右耳优势越明显。VDL右耳的表现与RBV的年变化率之间也存在正相关。感觉-运动测试与CCA无显著相关性。基线时T2病变负荷与基线时FT表现相关。人口统计学、临床和放射学（RBV和T2病变负荷）特征并没有混淆CCA和SDMT之间的显著关系。结论与RBV和T2病变负荷不同，CCA与SDMT相关，其表现为明显的认知成分而非知觉运动成分。
Bergendal G, Martola J, Stawiarz L, Kristoffersen-Wiberg M, Fredrikson S, Almkvist O. Callosal atrophy in multiple sclerosis is related to cognitive speed. Acta Neurol Scand: 2013: 127: 281-289. (C) 2012 John Wiley & Sons A/S. Background Long-term changes regarding corpus callosum area (CCA) and information processing speed in cognitive and sensory-motor tasks have rarely been studied in multiple sclerosis (MS). Objective and methods Information processing speed in cognitive (Symbol Digit Modalities Test, SDMT), sensory (visual and auditory reaction time) and motor (finger-tapping speed, FT; right and left hand) tasks as well as auditory inter-hemispheric transfer (verbal dichotic listening, VDL) was related to CCA, measured by MRI at baseline and at follow-up after nine years in 22 patients with MS. Possible confounding by demographic (age, gender and education), clinical (symptom onset, duration, severity of disease) and relative brain volume (RBV) as well as T2 lesion load was taken into account. Results The smaller the CCA at baseline, the slower was SDMT performance at baseline. In a similar way, CCA at follow-up was associated with poor SDMT result at follow-up. Furthermore, the higher the annual rate of change in CCA, the poorer was performance in VDL on the left ear and the more pronounced was the right ear advantage. A positive relationship between performance in VDL right ear and annual rate of change in RBV was also seen. Sensory-motor tests were not significantly associated with CCA. T2 lesion load at baseline was associated with FT performance at baseline. Demographic, clinical and radiological (RBV and T2 lesion load) characteristics did not confound the significant relation between CCA and SDMT. Conclusions CCA unlike RBV and T2 lesion load was associated with SDMT, which indicated a marked cognitive rather than perceptual-motor component.