Frequency and impact of symptoms experienced by patients with systemic sclerosis: results from a Canadian National Survey
Frequency and impact of symptoms experienced by patients with systemic sclerosis: results from a Canadian National Survey
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DOI：
10.1093/rheumatology/keq310
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发表时间：
2011-04-01
期刊：
影响因子：
5.5
通讯作者：
Thombs, Brett D.
中科院分区：
文献类型：
--
作者：
Bassel, Marielle;Hudson, Marie;Thombs, Brett D.
方法.共有464名SSc患者回答了加拿大硬皮病患者健康问题和研究重点调查，包括关于69种SSc症状的频率和影响的问题。进行描述性分析，将症状频率分为从不或很少与有时，大多数时间或总是，症状对日常活动的影响为无或轻微影响与中度至重度影响。就频率和对日常活动的中度至重度影响而言，五种最高评级的症状分别为：疲劳（89和72%）、RP（86和67%）、手僵硬（81和59%）、关节疼痛（81和64%）和睡眠困难（76和59%）。除了这些症状外，与手功能下降（握拳困难和难以握住物体）和疼痛（肌肉疼痛和关节压痛）相关的项目经常被认可，通常与日常活动的中度至重度影响相关。这项研究证实了SSc核心症状（如疼痛、疲劳和手功能受限）对生活质量的重要性。它还确定了研究很少的领域，如睡眠问题，这些领域似乎在日常功能中发挥重要作用，值得更有针对性的研究。
Methods. A total of 464 persons with SSc responded to the Canadian Scleroderma Patient Survey of Health Concerns and Research Priorities, including questions regarding the frequency and impact of 69 SSc symptoms. Descriptive analyses were performed dichotomizing symptom frequencies as never or rarely vs sometimes, most of the time or always and symptom impact on daily activities as no or minimal impact vs moderate to severe impact.Results. The five highest rated symptoms in terms of frequency and moderate to severe impact on daily activities, respectively, were: fatigue (89 and 72%), RP (86 and 67%), hand stiffness (81 and 59%), joint pain (81 and 64%) and difficulty sleeping (76 and 59%). In addition to these symptoms, items related to decreased hand function (difficulty making a fist and difficulty holding objects) and pain (muscle pain and joint tenderness) were frequently endorsed and commonly associated with moderate to severe impact on daily activities.Conclusion. This study confirmed the importance for quality of life of core symptoms of SSc, such as pain, fatigue and limitations in hand function. It also identified areas with very little research, such as sleep problems, that appear to play important roles in daily functioning, and that merit more focused study.