Advance of autophagy in chronic kidney diseases.
Advance of autophagy in chronic kidney diseases.
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自噬在慢性肾脏病中的研究进展
DOI：
10.1080/0886022x.2016.1274662
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发表时间：
2017-11
期刊：
影响因子：
3
通讯作者：
Zhang A
中科院分区：
文献类型：
--
作者：
Deng X;Xie Y;Zhang A
摘要 自噬是一种高度保守的细胞生存机制，是许多生物过程和疾病条件中的重要途径。对培养肾细胞、人类肾组织和实验动物模型的研究表明，自噬调节是慢性肾脏病 (CKD) 的关键方面。在此，我们总结了目前关于自噬在 CKD 中的作用的研究。揭示 CKD 中自噬的精确调节机制对于开发这些棘手的临床挑战的潜在预防、诊断和治疗靶点至关重要。
Abstract Autophagy, a highly conserved mechanism for cell survival, emerges as an important pathway in many biological processes and diseases conditions. Studies of cultured renal cells, human kidney tissues and experimental animal models implicate that autophagy regulation is the critical aspects in chronic kidney diseases (CKD). Here, we summarize the current studies on the role of autophagy in CKD. Unveiling the precise regulation mechanism of autophagy in CKD is essential for developing potential prevention, diagnostic and therapeutic targets of these sticky clinical challenges.