Tumorigenesis
Tumorigenesis
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DOI：
10.1007/978-3-540-74386-6_1
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Tapio, Soile
中科院分区：
文献类型：
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作者：
Atkinson, Michael J.;Tapio, Soile
肿瘤细胞具有一系列与正常细胞不同的遗传表型特征。它们获得了经历几乎持续不受管制的生长的能力，抵抗细胞毒性化学物质，并能够从它们的初始位置转移到不适当的组织隔间中增殖。本章描述了肿瘤发生的早期阶段，从基因突变和基因表达和生物信号的改变开始，最后讨论了遗传或环境因素加速了恶性肿瘤的启动过程。
Tumor cells possess a range of inherited phenotypic features that distinguish them from normal cells. They acquire the ability to undergo almost continual unregulated growth, resist cytotoxic chemicals and are able to metastasise from their initial locations to proliferate in inappropriate tissue compartments. This chapter describes the early stages of tumorigenesis, starting with genetic mutations and alterations in gene expression and biological signalling, and finally discusses inherited or environmental factors accelerating the initiative process to malignancy.