Comprehensive genomics linking between neural development and cancer: neuroblastoma as a model
Comprehensive genomics linking between neural development and cancer: neuroblastoma as a model
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DOI：
10.1016/s0304-3835(03)00457-9
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发表时间：
2004-02-20
期刊：
影响因子：
9.7
通讯作者：
Ohira, M
中科院分区：
文献类型：
--
作者：
Nakagawara, A;Ohira, M
癌细胞来源于它们的前体细胞，这些前体细胞通常发育成成熟细胞以形成单个器官。神经母细胞瘤。最常见的儿科实体瘤之一，起源于神经嵴来源的可能的癌症干细胞。在发育过程中，神经嵴细胞分化为感觉神经元、肠神经元和交感神经元。然而，导致神经母细胞瘤的遗传事件仅发生在交感神经前体细胞或癌症干细胞中。此外，在一岁以下的患者中发现的神经母细胞瘤的子集的自发消退模仿在围产期期间在正常交感神经元中发生的发育程序性神经元细胞死亡。因此，导致神经母细胞瘤的遗传事件可能被编程为以谱系特异性以及发育调节的方式发生。本文就神经发育与神经母细胞瘤发生之间的分子联系作一综述。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
Cancer cells are derived from their precursor cells, which normally develop to the matured cells to form individual organs. Neuroblastoma. one of the most common pediatric solid tumors, originates from possible cancer stem cells derived from the neural crest. During the development, neural crest cells segregate into several lineages such as sensory, enteric and sympathetic neurons. However, the genetic events to cause neuroblastoma occur only in the sympathetic precursor cells or cancer stem cells. Furthermore, spontaneous regression of a subset of neuroblastoma found in patients under one year of age mimics a developmentally programmed neuronal cell death that occurs in normal sympathetic neurons during the perinatal period. Thus, the genetic events to cause neuroblastoma may be programmed to occur in a lineage-specific as well as developmentally regulated manner. In this review, we discuss about the molecular link between neural development and the genesis of neuroblastoma based on our comprehensive genomics approach. (C) 2003 Elsevier Ireland Ltd. All rights reserved.