Newly isolated marine Bacillus pumilus (SP21): A source of novel lipoamides and other antimicrobial agents
Newly isolated marine Bacillus pumilus (SP21): A source of novel lipoamides and other antimicrobial agents
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DOI：
10.1351/pac-con-08-09-25
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发表时间：
2009-06-01
影响因子：
1.8
通讯作者：
Kerr, Russell G.
中科院分区：
文献类型：
--
作者：
Berrue, Fabrice;Ibrahim, Abdelnasser;Kerr, Russell G.
筛选海洋细菌的抗微生物活性导致分离短小芽孢杆菌（SP21）。来自巴哈马群岛的沉积物样本生物测定引导的分级分离导致五种表面活性素类似物、甘氨胆酸、amicoumacins A和B以及三种名为硫辛酰胺A-C的新化合物的分离。所有的生物活性化合物的化学结构进行了阐明，使用光谱方法，包括2D NMR和MS。每种化合物的抗微生物活性进行了评估，对一组病原体，并在此报告。
A screening of marine bacteria for antimicrobial activity resulted in the isolation of Bacillus pumilus (SP21.) from a sediment sample collected in the Bahamas. A bioassay-guided fractionation led to the isolation of five surfactin analogs, glycocholic acid, amicoumacins A and B in addition to three new compounds named lipoamides A-C. The chemical structure of all the bioactive compounds was elucidated using spectroscopic methods including 2D NMR and MS. The antimicrobial activity of each compound was evaluated against a panel of pathogens and is reported herein.