Cumulative benefits of frontal transcranial direct current stimulation on visuospatial working memory training and skill learning in rats
Cumulative benefits of frontal transcranial direct current stimulation on visuospatial working memory training and skill learning in rats
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DOI：
10.1016/j.nlm.2011.06.018
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发表时间：
2011-10-01
影响因子：
2.7
通讯作者：
Wesierska, Malgorzata J.
中科院分区：
文献类型：
--
作者：
Dockery, Colleen A.;Liebetanz, David;Wesierska, Malgorzata J.
经颅直流电刺激（tDCS）前额叶皮质可以无创地改变皮质活动，已被证明可以影响人类的执行功能。我们假设，tDCS的兴奋性变化，发现改善认知功能依赖于适度的前额叶皮层活动，将在动物和人类中类似地运作。为了验证这一点，我们使用大鼠视觉空间工作记忆和技能学习的行为模型与额叶皮层的tDCS配对进行实验。阳极/阴极tDCS的效果进行了检查，在三个会话中使用的替代位置回避交替任务（APAAT），后来重新检查没有刺激。刺激对正在进行的位置回避学习没有可测量的短期影响。然而，在第21天的随访中，与对照组相比，先前用阴极tDCS治疗的大鼠显示出显著更有效的位置回避和技能保持。这证明了当与新任务中的工作记忆和技能学习训练配对时，额叶tDCS减少兴奋性的长期益处。所提出的行为模型提供了一个工具，以评估的潜在机制，如何tDCS调节神经网络功能，以支持成功的行为。(C)2011 Elsevier Inc. All rights reserved.
Transcranial direct current stimulation (tDCS) of the prefrontal cortex, which non-invasively alters cortical activity, has been established to affect executive functions in humans. We hypothesized that changes in excitability by tDCS, found to improve cognitive functions dependent on moderate prefrontal cortex activity, would operate similarly in animals as in humans. To verify this we performed experiments using a rat behavioral model of visuospatial working memory and skill learning paired with tDCS of the frontal cortex. The effect of anodal/cathodal tDCS was examined in three sessions using the allothetic place avoidance alternation task (APAAT) and later re-examined without stimulation. Stimulation had no measurable short term effect on on-going place avoidance learning. However, in the follow-up session on day 21 the rats previously treated with cathodal tDCS showed significantly more efficient place avoidance and skill retention in comparison to the controls. This demonstrates a long-term benefit of diminished excitability by frontal tDCS when paired with training on working memory and skill learning in a novel task. The presented behavioral model provides a tool to evaluate the underlying mechanisms of how tDCS modulates neural network function to support successful behavior. (C) 2011 Elsevier Inc. All rights reserved.