Production of water-soluble few-layer graphene mesosheets by dry milling with hydrophobic drug.
Production of water-soluble few-layer graphene mesosheets by dry milling with hydrophobic drug.
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DOI：
10.1021/la5038475
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发表时间：
2014-12
期刊：
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通讯作者：
N. Rubio;Rui Serra-Maia;H. Kafa;Kuo-Ching Mei;E. Pach;William Luckhurst;M. Zloh;F. Festy;J. Richardson;J. Naglik;B. Ballesteros;K. Al‐Jamal
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文献类型：
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作者：
N. Rubio;Rui Serra-Maia;H. Kafa;Kuo-Ching Mei;E. Pach;William Luckhurst;M. Zloh;F. Festy;J. Richardson;J. Naglik;B. Ballesteros;K. Al‐Jamal
开发了一种新的、快速、简单的机械力化学(干磨)方法，用疏水药物剥离石墨烯，得到厚度为10 nm、宽度为∼1μm的几层石墨烯介质片。与Hummers法制备的氧化石墨烯相比，球磨处理后的石墨烯结构的电子性质得到了部分保留。利用热重分析、拉曼光谱、原子力显微镜、电子显微镜和分子动力学模拟等手段对该材料进行了表征。药物剥离的石墨烯中膜在药理上没有活性，为疏水药物干磨制备主要用作剥离剂的水溶性少层石墨烯介膜提供了一种新的方法。
A novel, fast, and easy mechano-chemistry-based (dry milling) method has been developed to exfoliate graphene with hydrophobic drugs generating few-layer graphene mesosheets (< 10 nm in thickness and ∼1 μm in width). The electronic properties of the graphitic structure were partially preserved after the milling treatment compared with graphene oxide prepared by Hummers' method. Several characterization techniques such as thermogravimetric analysis, Raman spectroscopy, atomic force microscopy, electron microscopy, and molecular dynamics simulation were used to characterize this material. The drug-exfoliated mesosheets were pharmacologically inactive, offering a new approach for making water-soluble few-layer graphene mesosheets upon dry milling with hydrophobic drugs, mainly used as exfoliating agents.