Discharge of the readily releasable pool with action potentials at hippocampal synapses
Discharge of the readily releasable pool with action potentials at hippocampal synapses
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DOI：
10.1152/jn.00857.2007
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发表时间：
2007-12-01
影响因子：
2.5
通讯作者：
Williams, James H.
中科院分区：
文献类型：
--
作者：
Stevens, Charles F.;Williams, James H.
海马突触动作电位易释放池的放电。J Neurophysiol 98：3221-3229，2007.首次发表于2007年10月17日; doi：10.1152/jn.00857.2007。一个容易释放池（RRP）的突触囊泡已被确定在海马突触与应用高渗溶液。RRP的大小与突触功能的重要性质相关，如释放概率。然而，据报道，RRP大小存在差异，具体取决于用于诱发突触释放的方法。本研究旨在确定高渗溶液定义的RRP与动作电位序列释放的RRP之间的定量关系。我们发现，在细胞培养突触的异步释放有助于显着的RRP与列车的动作电位和RRP的大小是相同的，当引起的神经刺激或高渗的挑战放电。
Discharge of the readily releasable pool with action potentials at hippocampal synapses. J Neurophysiol 98: 3221-3229, 2007. First published October 17, 2007; doi:10.1152/jn.00857.2007. A readily releasable pool (RRP) of synaptic vesicles has been identified at hippocampal synapses with application of hypertonic solution. RRP size correlates with important properties of synaptic function such as release probability. However, a discrepancy in RRP size has been reported depending on the method used to evoke synaptic release. This study was undertaken to determine quantitative relationships between the RRP defined with hypertonic solution and that released with trains of action potentials. We find that asynchronous release at cell culture synapses contributes significantly to the discharge of the RRP with trains of action potentials and that RRP size is the same when elicited by either nerve stimuli or hypertonic challenge.