Contribution of excitatory amino acids to hypoglycemic counter-regulation
Contribution of excitatory amino acids to hypoglycemic counter-regulation
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兴奋性氨基酸对低血糖反调节的贡献
DOI：
10.1016/s0006-8993(01)02236-3
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发表时间：
2001
期刊：
影响因子：
2.9
通讯作者：
N. Abumrad
中科院分区：
文献类型：
--
作者：
P. Molina;N. Abumrad
我们确定了中枢n-甲基-d-天冬氨酸（NMDA）受体激活对胰岛素诱导的低血糖的神经内分泌反调节反应的贡献。在两组装有慢性血管导管和脑室内（i.c.v）插管的清醒犬中，测定了葡萄糖动力学、糖异生底物平衡和反调节激素反应。外周胰岛素输注（5 mU/kg / min，持续3小时）使血浆葡萄糖水平降低40%，葡萄糖出现率（Ra）增加2倍。这与甘油和乳酸的肝净摄取显著增加有关，而丙氨酸的肝净摄取没有任何变化。用MK-801（一种NMDA受体拮抗剂）进行体外循环预处理，使葡萄糖ra1升高（50%）以及甘油和乳酸的肝脏净摄取增加。低血糖升高血浆皮质醇（3倍至14.3±1 mg/dl）和肾上腺素水平（14倍至3811±172 pg/ml）， MK-801预处理可减弱这种应激反应（分别为30%和60%）。在对照组中，MK-801没有改变低血糖引起的去甲肾上腺素或胰高血糖素的增加。这些结果表明，在低血糖期间，中枢兴奋性氨基酸通过激活NMDA受体参与调节血糖调节反应，从而刺激交感肾上腺和下丘脑-垂体肾上腺轴。这一机制似乎在低血糖期间肝糖生成持续升高中起重要作用。
We determined the contribution of central N-methyl-d-aspartate (NMDA) receptor activation to the neuro-endocrine counter-regulatory response to insulin-induced hypoglycemia. Glucose kinetics, gluconeogenic substrate balance and counter-regulatory hormonal responses were determined in two groups of conscious dogs fitted with chronic vascular catheters and intracerebroventricular (i.c.v.) cannula. Peripheral insulin infusion (5 mU/kg per min for 3 h) decreased plasma glucose levels 40% and increased the rate of glucose appearance (Ra) 2-fold. This was associated with significant increases in net hepatic uptake of glycerol and lactate, without any change in the net hepatic uptake of alanine. i.c.v. pretreatment with MK-801, an NMDA receptor antagonist, blunted (50%) the rise in glucose Raas well as the increase in the net hepatic uptake of glycerol and lactate. Hypoglycemia increased plasma cortisol (3-fold to 14.3±1 mg/dl) and epinephrine levels (14-fold to 3811±172 pg/ml), and this stress response was attenuated (30% and 60%, respectively) by MK-801 pretreatment. In controls, MK-801 did not alter the increase in norepinephrine or glucagon elicited by hypoglycemia. These results indicate that during hypoglycemia, central excitatory amino acids contribute to the modulation of the glucoregulatory response through activation of NMDA receptors, resulting in stimulation of the sympathoadrenal and hypothalamic–pituitary adrenal axis. This mechanism appears to play an important role in the sustained elevation in hepatic glucose production during hypoglycemia.
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低血糖本身会刺激交感神经和肾上腺髓质活动，但与肾上腺髓质反应不同，前臂交感神经反应在最近的低血糖后不会减少。
影响因子：
7.7
作者：
Paramore,DS;Fanelli,CG;Shah,SD;Cryer,PE
通讯作者：
Cryer,PE
代谢型兴奋性氨基酸激动剂 (1S,3R)-ACPD 引起的代谢、激素和血流动力学变化。
DOI：
10.1152/ajpregu.1995.268.4.r1026
发表时间：
1995
期刊：
The American journal of physiology.
影响因子：
--
作者：
Lang,CH;Ajmal,M
通讯作者：
Ajmal,M
大鼠下丘脑和垂体中的谷氨酸受体。
影响因子：
4.8
作者：
Meeker,RB;Greenwood,RS;Hayward,JN
通讯作者：
Hayward,JN
谷氨酸兴奋性毒性：与低温停循环相关的神经损伤机制。
DOI：
--
发表时间：
1994
期刊：
The Journal of thoracic and cardiovascular surgery
影响因子：
--
作者：
Redmond,JM;Gillinov,AM;Zehr,KJ;Blue,ME;Troncoso,JC;Reitz,BA;Cameron,DE;Johnston,MV;Baumgartner,WA
通讯作者：
Baumgartner,WA
组胺能对神经血糖减少症的代谢作用的贡献。
DOI：
10.1152/ajpregu.1997.272.6.r1918
发表时间：
1997
期刊：
The American journal of physiology.
影响因子：
--
作者：
Molina,PE;Williams,P;Abumrad,NN
通讯作者：
Abumrad,NN