EFFECT OF ERYTHROMYCIN ADMINISTRATION ON UPPER GASTROINTESTINAL MOTILITY IN SCLERODERMA PATIENTS
EFFECT OF ERYTHROMYCIN ADMINISTRATION ON UPPER GASTROINTESTINAL MOTILITY IN SCLERODERMA PATIENTS
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DOI：
10.3109/00365529409092515
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发表时间：
1994-09-01
影响因子：
1.9
通讯作者：
MORELLI, A
中科院分区：
文献类型：
--
作者：
FIORUCCI, S;DISTRUTTI, E;MORELLI, A
背景：硬皮病患者常累及胃肠道。红霉素是一种大环内酯类抗生素，已被证明可加速正常人和糖尿病患者的胃排空。本研究探讨了急性红霉素给药对硬皮病胃肠道受累患者胃和胆囊运动的影响。方法：对12例硬皮病患者和14例健康人进行调查。每例受试者在4个不同日期接受调查。通过超声和测压法测定胃和胆囊排空和胃动力，并评价空腹患者或半固体餐后2 mg/kg/h红霉素的作用。结果如下：硬皮病患者半固体餐胃排空半衰期为121.3 ± 14.0 min（SE），健康人为45.7 ± 10.4 min（P < 0.01）。硬皮病患者胆囊排空高峰（95.0 ± 5.0min）晚于健康人（45.0 ± 8.0min）（P < 0.01）。在空腹受试者中，红霉素刺激胃和胆囊运动，如测压和超声检查所示，并且在餐前即刻给药时加速胃和胆囊排空（P < 0.01）。结论：红霉素加速硬皮病患者的胃和胆囊排空，可能有助于治疗这些患者的胃肠道运动异常。
Background: Gastrointestinal involvement is frequent in patients with scleroderma. Erythromycin, a macrolide antibiotic, has been shown to accelerate gastric emptying in normal subjects and diabetic patients. The present study investigated the effects of acute erythromycin administration on gastric and gallbladder motility in patients with scleroderma and gastrointestinal involvement. Methods: Twelve scleroderma patients and 14 healthy subjects were investigated. Each subject was investigated on 4 different days. Gastric and gallbladder emptying and gastric motility were determined by sonography and manometry, and the effect of 2 mg/kg/h erythromycin in fasted patients or after semisolid meal evaluated. Results: The half-time of gastric emptying in response to semisolid meal was 121.3 +/- 14.0 min (SE) in scleroderma patients and 45.7 +/- 10.4 min in healthy subjects (P < 0.01). The peak of gallbladder emptying occurred later in scleroderma patients (95.0 +/- 5.0 min) than in healthy subjects (45.0 +/- 8.0 min) (P < 0.01). Erythromycin stimulated gastric and gallbladder motility in fasted subjects, as shown by manometry and sonography, and accelerated gastric and gallbladder emptying when administered immediately before the meal (P < 0.01). Conclusions: Erythromycin accelerates gastric and gallbladder emptying in scleroderma patients and might be helpful in the treatment of gastrointestinal motor abnormalities in these patients.