When less is more: novel mechanisms of iron conservation.
When less is more: novel mechanisms of iron conservation.
复制标题
DOI：
10.1016/j.tem.2013.07.003
复制
发表时间：
2013-11
期刊：
影响因子：
--
通讯作者：
Ardehali H
中科院分区：
文献类型：
--
作者：
Bayeva M;Chang HC;Wu R;Ardehali H
铁稳态紊乱非常常见，但铁调节的分子机制仍未得到充分研究。自从铁调节蛋白 (IRP) 首次被描述为哺乳动物通过铁获取来调节细胞缺铁反应的介质以来，已经过去 20 多年了。然而，人们对适应低铁状态所需的其他机制知之甚少。在这篇综述中，我们提出了最新的证据，证明存在一种新的铁监管途径，旨在通过抑制非必需的铁消耗过程来保存铁和优化铁的利用。此外，我们讨论了缺铁反应研究发现的铁稳态和能量代谢之间可能的联系。
Disorders of iron homeostasis are very common, yet the molecular mechanisms of iron regulation remain understudied. Over 20 years have passed since the first characterization of iron regulatory proteins (IRP) as mediators of cellular iron deficiency response in mammals through iron acquisition. However, little is known about other mechanisms necessary for adaptation to low-iron states. In this review we present recent evidence that establishes existence of a new iron regulatory pathway aimed at iron conservation and optimization of iron use through suppression of non-essential iron-consuming processes. Moreover, we discuss the possible links between iron homeostasis and energy metabolism uncovered by studies of iron deficiency response.