Sensitivity analysis of geometrical parameters to study haemodynamics and thrombus formation in the left atrial appendage
Sensitivity analysis of geometrical parameters to study haemodynamics and thrombus formation in the left atrial appendage
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DOI：
10.1002/cnm.3100
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发表时间：
2018-08-01
影响因子：
2.1
通讯作者：
Camara, Oscar
中科院分区：
文献类型：
--
作者：
Garcia-Isla, Guadalupe;Luis Olivares, Andy;Camara, Oscar
左心耳（LAA）是左心房（LA）的一个复杂且不均匀的突出结构。在房颤患者中，90%的血栓都是在此处形成的。然而，左心耳在血栓形成中的作用尚不完全清楚。这项工作的主要目标是进行灵敏度分析，以确定心房血流动力学中最相关的LA和LAA形态参数。在合成椭圆形左心房模型上运行模拟，其中单独研究不同参数：肺静脉和二尖瓣尺寸; LAA形状;和LA体积。我们的计算分析证实了大的左心耳口，低血流速度和血栓形成之间的关系。此外，我们还发现肺静脉构型对左心耳血流模式有重要影响。这些发现有助于更好地了解左心耳，并支持房颤患者的临床决策。
The left atrial appendage (LAA) is a complex and heterogeneous protruding structure of the left atrium (LA). In atrial fibrillation patients, it is the location where 90% of the thrombi are formed. However, the role of the LAA in thrombus formation is not fully known yet. The main goal of this work is to perform a sensitivity analysis to identify the most relevant LA and LAA morphological parameters in atrial blood flow dynamics. Simulations were run on synthetic ellipsoidal left atria models where different parameters were individually studied: pulmonary veins and mitral valve dimensions; LAA shape; and LA volume. Our computational analysis confirmed the relation between large LAA ostia, low blood flow velocities and thrombus formation. Additionally, we found that pulmonary vein configuration exerted a critical influence on LAA blood flow patterns. These findings contribute to a better understanding of the LAA and to support clinical decisions for atrial fibrillation patients.