Enhancement in seroconversion to measles vaccine with simultaneous administration of vitamin A in 9-months-old Indian infants
Enhancement in seroconversion to measles vaccine with simultaneous administration of vitamin A in 9-months-old Indian infants
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DOI：
10.1007/bf02737757
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发表时间：
1997-01-01
影响因子：
4.3
通讯作者：
Rao, K. Visweswara
中科院分区：
文献类型：
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作者：
Bhaskaram, P.;Rao, K. Visweswara
本研究探讨了9月龄婴儿同时接种麻疹疫苗与维生素A剂量的相互作用。100名9个月大的健康婴儿在常规免疫诊所接种EZ株麻疹疫苗，同时口服100000国际单位的维生素A或服用安慰剂。分别于干预前和干预后4周采集血样。对它们进行编码并分析血清视黄醇和麻疹血凝抑制(HI)抗体。免疫前麻疹抗体阴转率为95%，对照组抗体阳转率为63%，试验组为83.7%(P<0.01)。在这两组患者中，血清转换率与初始血清视黄醇水平无关。42%的婴儿在接种疫苗前血清视黄醇水平低于20mU·g/dl，干预后两组婴儿维生素A水平均有改善，其中试验组由22.4±-1.32增加到26.0±1.07(P<0.05)。结果表明，大多数9个月大的婴儿麻疹血清呈阴性。常规免疫门诊麻疹疫苗阳转率较低。同时接种维生素A和麻疹疫苗对9个月大婴儿的维生素A状况和疫苗的血清转换率有良好的影响。
The mutual interactions of measles vaccine and vitamin A dose when administered simultaneously to 9 month old infants are explored in this study. One hundred healthy infants of 9 months of age received EZ strain of measles vaccine in the routine immunization clinic along will) either 100,000 IU of vitamin A or a placebo orally. Blood samples were collected before and 4 weeks after intervention. They were coded and analysed for serum retinol and Hemagglutination Inhibition (HI) antibodies to measles. Ninety five per cent of the infants were seronegative to measles prior to vaccination with a seroconversion rate of 63% in the control group and a significantly higher percent of 83.7% in the experimental group (P lt 0.01). Seroconversion was not related to initial serum retinol levels in either of the groups. 42% of infants had serum retinol levels less than 20 mu-g/dl before administration of the vaccine and both the groups showed improvement in vitamin A status following intervention, the increase being significant in the experimental group (from 22.4 +- 1.32 to 26.0 +- 1.07; P lt 0.05). The results indicate that majority of the infants at 9 months of age were seronegative to measles. Seroconversion to measles vaccine in the routine immunization clinics was low. Simultaneous administration of vitamin A and measles vaccine had beneficial effects on vitamin A status as well as seroconversion rates to the vaccine in 9 months old infants.