Treatment of Heart Failure Beyond Practice Guidelines
Treatment of Heart Failure Beyond Practice Guidelines
复制标题
超越实践指南的心力衰竭治疗
DOI：
--
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
D. Mann
中科院分区：
文献类型：
--
作者：
Arunima Misra;D. Mann
心力衰竭(HF)是一种临床综合征，其发生和发展是由于生物活性分子的过度表达，足以对心脏和循环造成有害影响。在过去的20年里，遵循治疗心力衰竭的实践指南，包括使用血管紧张素转换酶抑制剂/血管紧张素受体拮抗剂和β阻滞剂，提高了患者的存活率。然而，尽管使用了这些循证策略来阻断神经激素激活的有害影响，但心力衰竭的总死亡率仍然高得令人无法接受。不幸的是，当患者尽管优化了他们的医疗和/或设备治疗仍有症状时，改善患者发病率的“下一步”根本不清楚。因此，对于心力衰竭患者的治疗，仍有一个未得到满足的需求。综述了心脏重塑是心力衰竭疾病进展的重要机制这一概念，并讨论了几种旨在防止心脏重塑恶化的装置方面的新治疗策略。(保监会J 2008；附录A：A-1-A-7)
Heart failure (HF) is clinical syndrome that develops and progresses as a result of the overexpression of biologically active molecules that are sufficient to cause deleterious effects on the heart and circulation. Over the past 2 decades the adherence to practice guidelines for treating HF, including the use of angiotensin-converting enzyme inhibitors/angiotensin-receptor antagonists and β-blockers, has resulted in improved survival for patients. However, despite the use of these evidence-based strategies that block the deleterious effects of neurohormonal activation, the overall mortality for HF remains unacceptably high. Unfortunately, when patients remain symptomatic despite having their medical and/or device therapies optimized, the "next steps" to improving patient morbidity are not at all clear. Thus, there remains an unmet need with respect to the treatment of HF patients. The concept that cardiac remodeling represents an important mechanism for disease progression in HF is reviewed, as well as discussion of several novel treatment strategies with respect to devices that are intended to prevent worsening cardiac remodeling. (Circ J 2008; Suppl A: A-1 - A-7)
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影响因子：
37.8
作者：
Pouleur,H;Rousseau,MF;vanEyll,C;Melin,J;Youngblood,M;Yusuf,S
通讯作者：
Yusuf,S
心动过速引起的心力衰竭中心内膜下功能受损。
DOI：
10.1152/ajpheart.1995.268.5.h1788
发表时间：
1995
期刊：
The American journal of physiology.
影响因子：
--
作者：
LeGrice,IJ;Takayama,Y;Holmes,JW;Covell,JW
通讯作者：
Covell,JW
DOI：
10.1152/ajpheart.1993.265.3.h801
发表时间：
1993-09
期刊：
The American journal of physiology
影响因子：
--
作者：
R. Shannon;K. Komamura;Y. Shen;S. Bishop;S. Vatner
通讯作者：
R. Shannon;K. Komamura;Y. Shen;S. Bishop;S. Vatner
影响因子：
24
作者：
W. F. Saavedra;R. Tunin;N. Paolocci;T. Mishima;G. Suzuki;C. Emala;P. Chaudhry;P. Anagnostopoulos
通讯作者：
W. F. Saavedra;R. Tunin;N. Paolocci;T. Mishima;G. Suzuki;C. Emala;P. Chaudhry;P. Anagnostopoulos
影响因子：
37.8
作者：
Mann, DL
通讯作者：
Mann, DL